The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introd...

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Autores principales:	Junli Li, Lingjun Zhan, Chuan Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/546de3daadba442da33539035d701e32
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spelling	oai:doaj.org-article:546de3daadba442da33539035d701e322021-12-02T13:57:25ZThe double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine10.1038/s41541-020-00278-02059-0105https://doaj.org/article/546de3daadba442da33539035d701e322021-01-01T00:00:00Zhttps://doi.org/10.1038/s41541-020-00278-0https://doaj.org/toc/2059-0105Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.Junli LiLingjun ZhanChuan QinNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Junli Li Lingjun Zhan Chuan Qin The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
description	Abstract Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.
format	article
author	Junli Li Lingjun Zhan Chuan Qin
author_facet	Junli Li Lingjun Zhan Chuan Qin
author_sort	Junli Li
title	The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_short	The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full	The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_fullStr	The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full_unstemmed	The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_sort	double-sided effects of mycobacterium bovis bacillus calmette–guérin vaccine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/546de3daadba442da33539035d701e32
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The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

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