Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study

Linghong Guo,1 Fuqing Zhou,1 Ning Zhang,1 Hongmei Kuang,1 Zhen Feng2 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 2Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang Uni...

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Autores principales:	Guo L, Zhou F, Zhang N, Kuang H, Feng Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	alcohol dependence homotopic connectivity frequency band resting-state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/54701c4952e34dfdb5d7ca3d18a49366
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spelling	oai:doaj.org-article:54701c4952e34dfdb5d7ca3d18a493662021-12-02T04:40:38ZFrequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study1178-2021https://doaj.org/article/54701c4952e34dfdb5d7ca3d18a493662019-11-01T00:00:00Zhttps://www.dovepress.com/frequency-specific-abnormalities-of-functional-homotopy-in-alcohol-dep-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Linghong Guo,1 Fuqing Zhou,1 Ning Zhang,1 Hongmei Kuang,1 Zhen Feng2 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 2Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaCorrespondence: Zhen FengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Number 17, Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, People’s Republic of ChinaTel/Fax +86-791-88698601Email fengzhenly@sina.comPurpose: Alcohol dependence (AD) is a relapsing mental disorder, typically occurring with concurrent tobacco misuse. Studies have reported disruption of the structural connectivity between hemispheres in the brain of individuals with AD. However, alterations in interhemispheric interactions and the specificity of frequency bands in individuals with AD remain unknown. Voxel-mirrored homotopic connectivity (VMHC) allows examination of functional interactions between mirrored interhemispheric voxels. Here, we use VMHC to investigate homotopic connectivity in AD and alcohol and nicotine co-dependence (AND) subjects.Patients and methods: VMHC and seed-based functional connectivity (FC) in 24 AD, 30 AND, and 35 sex-, age-, and education-matched healthy control (HC) subjects were calculated for different frequency bands (slow-5, slow-4, and typical bands).Results: Individuals with AD demonstrated significantly reduced VMHC in bilateral cerebellum posterior lobe (CPL) and increased VMHC in bilateral middle frontal gyrus (MFG) compared to that in HCs in the typical and slow-4 bands; higher VMHC in the MFG was positively correlated with the dependence-severity score. In all bands of the VMHC analysis, no significant differences were found between the AND and other groups. Subsequent seed-based FC analysis demonstrated all regions with abnormal VMHC exhibited altered FC with its counterpart in the contralateral hemisphere in the typical and slow-4 frequency bands. The FC value between bilateral CPL within AD subjects negatively correlated with alcohol intake.Conclusion: Our findings provide further evidence of the role of disruptions within the brain circuitry supporting cognitive control in the development of AD. Alterations in neural activities in the CPL and MFG might be a biomarker of dependence severity in AD patients as assessed using clinical questionnaire and features. Because of the frequency specificity in VMHC, we must consider frequency effects in future AD functional magnetic resonance imaging studies.Keywords: alcohol, dependence, homotopic connectivity, frequency band, resting-state fMRIGuo LZhou FZhang NKuang HFeng ZDove Medical Pressarticlealcoholdependencehomotopic connectivityfrequency bandresting-state fmriNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3231-3245 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	alcohol dependence homotopic connectivity frequency band resting-state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	alcohol dependence homotopic connectivity frequency band resting-state fmri Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Guo L Zhou F Zhang N Kuang H Feng Z Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
description	Linghong Guo,1 Fuqing Zhou,1 Ning Zhang,1 Hongmei Kuang,1 Zhen Feng2 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 2Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaCorrespondence: Zhen FengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, Number 17, Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, People’s Republic of ChinaTel/Fax +86-791-88698601Email fengzhenly@sina.comPurpose: Alcohol dependence (AD) is a relapsing mental disorder, typically occurring with concurrent tobacco misuse. Studies have reported disruption of the structural connectivity between hemispheres in the brain of individuals with AD. However, alterations in interhemispheric interactions and the specificity of frequency bands in individuals with AD remain unknown. Voxel-mirrored homotopic connectivity (VMHC) allows examination of functional interactions between mirrored interhemispheric voxels. Here, we use VMHC to investigate homotopic connectivity in AD and alcohol and nicotine co-dependence (AND) subjects.Patients and methods: VMHC and seed-based functional connectivity (FC) in 24 AD, 30 AND, and 35 sex-, age-, and education-matched healthy control (HC) subjects were calculated for different frequency bands (slow-5, slow-4, and typical bands).Results: Individuals with AD demonstrated significantly reduced VMHC in bilateral cerebellum posterior lobe (CPL) and increased VMHC in bilateral middle frontal gyrus (MFG) compared to that in HCs in the typical and slow-4 bands; higher VMHC in the MFG was positively correlated with the dependence-severity score. In all bands of the VMHC analysis, no significant differences were found between the AND and other groups. Subsequent seed-based FC analysis demonstrated all regions with abnormal VMHC exhibited altered FC with its counterpart in the contralateral hemisphere in the typical and slow-4 frequency bands. The FC value between bilateral CPL within AD subjects negatively correlated with alcohol intake.Conclusion: Our findings provide further evidence of the role of disruptions within the brain circuitry supporting cognitive control in the development of AD. Alterations in neural activities in the CPL and MFG might be a biomarker of dependence severity in AD patients as assessed using clinical questionnaire and features. Because of the frequency specificity in VMHC, we must consider frequency effects in future AD functional magnetic resonance imaging studies.Keywords: alcohol, dependence, homotopic connectivity, frequency band, resting-state fMRI
format	article
author	Guo L Zhou F Zhang N Kuang H Feng Z
author_facet	Guo L Zhou F Zhang N Kuang H Feng Z
author_sort	Guo L
title	Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
title_short	Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
title_full	Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
title_fullStr	Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
title_full_unstemmed	Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study
title_sort	frequency-specific abnormalities of functional homotopy in alcohol dependence: a resting-state functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/54701c4952e34dfdb5d7ca3d18a49366
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Frequency-Specific Abnormalities Of Functional Homotopy In Alcohol Dependence: A Resting-State Functional Magnetic Resonance Imaging Study

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