Identifying noncoding risk variants using disease-relevant gene regulatory networks

Código QR

Identifying noncoding risk variants using disease-relevant gene regulatory networks

Current methods for prioritization of non-coding genetic risk variants are based on sequence and chromatin features. Here, Gao et al. develop ARVIN, which predicts causal regulatory variants using disease-relevant gene-regulatory networks, and validate this approach in reporter gene assays.

Guardado en:

Detalles Bibliográficos
Autores principales:	Long Gao, Yasin Uzun, Peng Gao, Bing He, Xiaoke Ma, Jiahui Wang, Shizhong Han, Kai Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5472bfb79e7346c78601c129c375ba8e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Biological relevance of computationally predicted pathogenicity of noncoding variants
por: Li Liu, et al.
Publicado: (2019)

Consistent robustness analysis (CRA) identifies biologically relevant properties of regulatory network models.
por: Treenut Saithong, et al.
Publicado: (2010)

Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
por: D. Wragg, et al.
Publicado: (2020)

Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer
por: Zhou Du, et al.
Publicado: (2016)

Regulatory Noncoding Small RNAs Are Diverse and Abundant in an Extremophilic Microbial Community
por: Diego R. Gelsinger, et al.
Publicado: (2020)

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer
por: Stanley Zhou, et al.
Publicado: (2020)

Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study
por: Amin Emad, et al.
Publicado: (2021)

Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
por: Matthew C. Pahl, et al.
Publicado: (2021)

Identifying the Most Critical Intersections in Transportation Networks
por: Emre Kuşkapan*, et al.
Publicado: (2021)

Identifying topologically associating domains and subdomains by Gaussian Mixture model And Proportion test
por: Wenbao Yu, et al.
Publicado: (2017)

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
por: Angli Xue, et al.
Publicado: (2018)

Profile of Basal Cell Carcinoma Mutations and Copy Number Alterations - Focus on Gene-Associated Noncoding Variants
por: Paulina Maria Nawrocka, et al.
Publicado: (2021)

NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
por: Joseph R. Scarpa, et al.
Publicado: (2021)

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
por: Runqiu Jiang, et al.
Publicado: (2017)

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
por: Qipan Deng, et al.
Publicado: (2019)

The role of hypoxia-induced long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis
por: Pei-Hua Peng, et al.
Publicado: (2021)

Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma
por: Y. Liu, et al.
Publicado: (2017)

Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs
por: Tetsuya Hirata, et al.
Publicado: (2018)

Breast cancer associated germline structural variants harboring small noncoding RNAs impact post-transcriptional gene regulation
por: Mahalakshmi Kumaran, et al.
Publicado: (2018)

Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information
por: Sebastian Guelfi, et al.
Publicado: (2020)

MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors
por: Lun-Xi Peng, et al.
Publicado: (2021)

Long noncoding RNA expression analysis reveals the regulatory effects of nitinol-based nanotubular coatings on human coronary artery endothelial cells
por: Shang P, et al.
Publicado: (2019)

The role of long noncoding RNA in traumatic brain injury
por: Li Z, et al.
Publicado: (2019)

Identifying critical edges in complex networks
por: En-Yu Yu, et al.
Publicado: (2018)

Exploring functions of long noncoding RNAs across multiple cancers through co-expression network
por: Suqing Li, et al.
Publicado: (2017)

Gene regulatory network analysis identifies key genes and regulatory mechanisms involved in acute myocardial infarction using bulk and single cell RNA-seq data
por: Jiaxin Luo, et al.
Publicado: (2021)

Effect of selection bias on two sample summary data based Mendelian randomization
por: Kai Wang, et al.
Publicado: (2021)

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks
por: André F. Rendeiro, et al.
Publicado: (2016)

Functional testing of thousands of osteoarthritis-associated variants for regulatory activity
por: Jason C. Klein, et al.
Publicado: (2019)

Identifying causal variants by fine mapping across multiple studies.
por: Nathan LaPierre, et al.
Publicado: (2021)

Relevance of pathogenicity prediction tools in human RYR1 variants of unknown significance
por: Kerstin Hoppe, et al.
Publicado: (2021)

A New Noncoding RNA Arranges Bacterial Chromosome Organization
por: Zhong Qian, et al.
Publicado: (2015)

Relevant Issues Determining the Effectiveness of Policy Networks
por: Ruslan Rinatovich Abezgildin
Publicado: (2018)

Beyond Trinucleotide Repeat Expansion in Fragile X Syndrome: Rare Coding and Noncoding Variants in <i>FMR1</i> and Associated Phenotypes
por: Cedrik Tekendo-Ngongang, et al.
Publicado: (2021)

Identifying cis-regulatory sequences by word profile similarity.
por: Garmay Leung, et al.
Publicado: (2009)

Inference of Bacterial Small RNA Regulatory Networks and Integration with Transcription Factor-Driven Regulatory Networks
por: Mario L. Arrieta-Ortiz, et al.
Publicado: (2020)

A bio-inspired methodology of identifying influential nodes in complex networks.
por: Cai Gao, et al.
Publicado: (2013)

Long noncoding RNAs and Alzheimer's disease
por: Luo Q, et al.
Publicado: (2016)

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
por: Julian Musa, et al.
Publicado: (2019)

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
por: Tatsuya Tsukui, et al.
Publicado: (2020)