Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study

Abstract Background Secondary poor graft function (sPGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) related to poor outcome. We aimed to retrospectively evaluate the morbidity and hazard elements of sPGF after allo‐HSCT. Methods Eight hundred and s...

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Autores principales:	Wei‐Ran Lv, Ya Zhou, Jun Xu, Zhi‐Ping Fan, Fen Huang, Na Xu, Li Xuan, Peng‐Cheng Shi, Hui Liu, Zhi‐Xiang Wang, Jing Sun, Qi‐Fa Liu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	haploidentical donor transplant hazard elements hematopoietic stem cell transplantation secondary poor graft function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5476aeff76f8453bb3b98e200d363d32
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spelling	oai:doaj.org-article:5476aeff76f8453bb3b98e200d363d322021-12-01T04:49:15ZHaploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study2045-763410.1002/cam4.4353https://doaj.org/article/5476aeff76f8453bb3b98e200d363d322021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4353https://doaj.org/toc/2045-7634Abstract Background Secondary poor graft function (sPGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) related to poor outcome. We aimed to retrospectively evaluate the morbidity and hazard elements of sPGF after allo‐HSCT. Methods Eight hundred and sixty‐three patients who achieved initial engraftment of both neutrophils and platelets were retrospectively reviewed in this study. Results Fifty‐two patients developed sPGF within 180 days post‐transplants, with the median onset time was 62 days (range, 34–121 days) post‐transplants. The overall cumulative incidence of sPGF within 180 days post‐transplantation was 6.0%, with 3.4%, 3.4%, and 10.1%, respectively, in matched sibling donor (MSD), matched unrelated donor (MUD), and haploidentical donor (HID) transplant (p < 0.0001). Multivariable analysis showed that HID (HID vs. MSD: hazard ratio [HR] 2.525, p = 0.004; HID vs. MUD: [HR] 3.531, p = 0.017), acute graft versus host disease (aGVHD) within +30 days ([HR] 2.323, p = 0.003), and cytomegalovirus (CMV) reactivation ([HR] 8.915, p < 0.0001) within +30 days post‐transplants were hazard elements of sPGF. The patients with sPGF had poorer survival than good graft function (51.7±8.1% vs. 62.9±1.9%, p < 0.0001). Our results also showed that only CMV reactivation was the hazard element for the development of PGF in HID transplant ([HR] 12.521 p < 0.0001). Conclusion HID transplant is also an independent hazard element of sPGF except for aGVHD and CMV reactivation.Wei‐Ran LvYa ZhouJun XuZhi‐Ping FanFen HuangNa XuLi XuanPeng‐Cheng ShiHui LiuZhi‐Xiang WangJing SunQi‐Fa LiuWileyarticlehaploidentical donor transplanthazard elementshematopoietic stem cell transplantationsecondary poor graft functionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8497-8506 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	haploidentical donor transplant hazard elements hematopoietic stem cell transplantation secondary poor graft function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	haploidentical donor transplant hazard elements hematopoietic stem cell transplantation secondary poor graft function Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wei‐Ran Lv Ya Zhou Jun Xu Zhi‐Ping Fan Fen Huang Na Xu Li Xuan Peng‐Cheng Shi Hui Liu Zhi‐Xiang Wang Jing Sun Qi‐Fa Liu Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
description	Abstract Background Secondary poor graft function (sPGF) is a serious complication after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) related to poor outcome. We aimed to retrospectively evaluate the morbidity and hazard elements of sPGF after allo‐HSCT. Methods Eight hundred and sixty‐three patients who achieved initial engraftment of both neutrophils and platelets were retrospectively reviewed in this study. Results Fifty‐two patients developed sPGF within 180 days post‐transplants, with the median onset time was 62 days (range, 34–121 days) post‐transplants. The overall cumulative incidence of sPGF within 180 days post‐transplantation was 6.0%, with 3.4%, 3.4%, and 10.1%, respectively, in matched sibling donor (MSD), matched unrelated donor (MUD), and haploidentical donor (HID) transplant (p < 0.0001). Multivariable analysis showed that HID (HID vs. MSD: hazard ratio [HR] 2.525, p = 0.004; HID vs. MUD: [HR] 3.531, p = 0.017), acute graft versus host disease (aGVHD) within +30 days ([HR] 2.323, p = 0.003), and cytomegalovirus (CMV) reactivation ([HR] 8.915, p < 0.0001) within +30 days post‐transplants were hazard elements of sPGF. The patients with sPGF had poorer survival than good graft function (51.7±8.1% vs. 62.9±1.9%, p < 0.0001). Our results also showed that only CMV reactivation was the hazard element for the development of PGF in HID transplant ([HR] 12.521 p < 0.0001). Conclusion HID transplant is also an independent hazard element of sPGF except for aGVHD and CMV reactivation.
format	article
author	Wei‐Ran Lv Ya Zhou Jun Xu Zhi‐Ping Fan Fen Huang Na Xu Li Xuan Peng‐Cheng Shi Hui Liu Zhi‐Xiang Wang Jing Sun Qi‐Fa Liu
author_facet	Wei‐Ran Lv Ya Zhou Jun Xu Zhi‐Ping Fan Fen Huang Na Xu Li Xuan Peng‐Cheng Shi Hui Liu Zhi‐Xiang Wang Jing Sun Qi‐Fa Liu
author_sort	Wei‐Ran Lv
title	Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
title_short	Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
title_full	Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
title_fullStr	Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
title_full_unstemmed	Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study
title_sort	haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: a single‐center retrospective study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/5476aeff76f8453bb3b98e200d363d32
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Haploidentical donor transplant is associated with secondary poor graft function after allogeneic stem cell transplantation: A single‐center retrospective study

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