Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PF...
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Nature Portfolio
2017
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oai:doaj.org-article:54773ae57086423bbfe78d47470a22d62021-12-02T15:36:58ZSnail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress10.1038/ncomms143742041-1723https://doaj.org/article/54773ae57086423bbfe78d47470a22d62017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14374https://doaj.org/toc/2041-1723Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PFKP.Nam Hee KimYong Hoon ChaJueun LeeSeon-Hyeong LeeJi Hye YangJun Seop YunEunae Sandra ChoXianglan ZhangMiso NamNami KimYoung-Su YukSo Young ChaYoonmi LeeJoo Kyung RyuSunghyouk ParkJae-Ho CheongSang Won KangSoo-Youl KimGeum-Sook HwangJong In YookHyun Sil KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Nam Hee Kim Yong Hoon Cha Jueun Lee Seon-Hyeong Lee Ji Hye Yang Jun Seop Yun Eunae Sandra Cho Xianglan Zhang Miso Nam Nami Kim Young-Su Yuk So Young Cha Yoonmi Lee Joo Kyung Ryu Sunghyouk Park Jae-Ho Cheong Sang Won Kang Soo-Youl Kim Geum-Sook Hwang Jong In Yook Hyun Sil Kim Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| description |
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate pathway through repression of phosphofructokinase PFKP. |
| format |
article |
| author |
Nam Hee Kim Yong Hoon Cha Jueun Lee Seon-Hyeong Lee Ji Hye Yang Jun Seop Yun Eunae Sandra Cho Xianglan Zhang Miso Nam Nami Kim Young-Su Yuk So Young Cha Yoonmi Lee Joo Kyung Ryu Sunghyouk Park Jae-Ho Cheong Sang Won Kang Soo-Youl Kim Geum-Sook Hwang Jong In Yook Hyun Sil Kim |
| author_facet |
Nam Hee Kim Yong Hoon Cha Jueun Lee Seon-Hyeong Lee Ji Hye Yang Jun Seop Yun Eunae Sandra Cho Xianglan Zhang Miso Nam Nami Kim Young-Su Yuk So Young Cha Yoonmi Lee Joo Kyung Ryu Sunghyouk Park Jae-Ho Cheong Sang Won Kang Soo-Youl Kim Geum-Sook Hwang Jong In Yook Hyun Sil Kim |
| author_sort |
Nam Hee Kim |
| title |
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| title_short |
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| title_full |
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| title_fullStr |
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| title_full_unstemmed |
Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress |
| title_sort |
snail reprograms glucose metabolism by repressing phosphofructokinase pfkp allowing cancer cell survival under metabolic stress |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/54773ae57086423bbfe78d47470a22d6 |
| work_keys_str_mv |
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