Brain metabolite values in children with breath-holding spells

Mustafa Calik,1 Dilek Sen Dokumaci,2 Suna Sarikaya,3 Mahmut Demir,4 Ilhan Isik,5 Halil Kazanasmaz,4 Cemil Kaya,4 Hasan Kandemir6 1Department of Pediatric Neurology, 2Department of Radiology, 3Department of Neurology, 4Department of Pediatrics, Harran University School of Medicine, 5Department of Pe...

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Autores principales:	Calik M, Sen Dokumaci D, Sarikaya S, Demir M, Isik I, Kazanasmaz H, Kaya C, Kandemir H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	breath-holding spells neuronal damage children magnetic resonance spectroscopy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/547797fac96c4656b09089d4fb738a3e
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id	oai:doaj.org-article:547797fac96c4656b09089d4fb738a3e
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spelling	oai:doaj.org-article:547797fac96c4656b09089d4fb738a3e2021-12-02T00:08:26ZBrain metabolite values in children with breath-holding spells1178-2021https://doaj.org/article/547797fac96c4656b09089d4fb738a3e2017-06-01T00:00:00Zhttps://www.dovepress.com/brain-metabolite-values-in-children-with-breath-holding-spells-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mustafa Calik,1 Dilek Sen Dokumaci,2 Suna Sarikaya,3 Mahmut Demir,4 Ilhan Isik,5 Halil Kazanasmaz,4 Cemil Kaya,4 Hasan Kandemir6 1Department of Pediatric Neurology, 2Department of Radiology, 3Department of Neurology, 4Department of Pediatrics, Harran University School of Medicine, 5Department of Pediatric Neurology, Eyyubiye Training and Research Hospital, 6Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey Abstract: Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. Keywords: brain metabolite, children, breath holding, magnetic resonance spectroscopy Calik MSen Dokumaci DSarikaya SDemir MIsik IKazanasmaz HKaya CKandemir HDove Medical Pressarticlebreath-holding spellsneuronal damagechildrenmagnetic resonance spectroscopyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1655-1660 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	breath-holding spells neuronal damage children magnetic resonance spectroscopy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	breath-holding spells neuronal damage children magnetic resonance spectroscopy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Calik M Sen Dokumaci D Sarikaya S Demir M Isik I Kazanasmaz H Kaya C Kandemir H Brain metabolite values in children with breath-holding spells
description	Mustafa Calik,1 Dilek Sen Dokumaci,2 Suna Sarikaya,3 Mahmut Demir,4 Ilhan Isik,5 Halil Kazanasmaz,4 Cemil Kaya,4 Hasan Kandemir6 1Department of Pediatric Neurology, 2Department of Radiology, 3Department of Neurology, 4Department of Pediatrics, Harran University School of Medicine, 5Department of Pediatric Neurology, Eyyubiye Training and Research Hospital, 6Department of Child and Adolescent Psychiatry, Harran University School of Medicine, Sanliurfa, Turkey Abstract: Breath-holding spells are benign, paroxysmal events with apnea and postural tone changes after a crying episode in infants. The objective of this study was to investigate the pathologies in brain metabolite values in the absence of seizure in children with breath-holding spells by using magnetic resonance spectroscopy (MRS). Brain MRS examination was performed on 18 children with breath-holding spells and 13 neurologically normal children who were included as the control group. There was no significant difference in terms of N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (mI) levels and also in terms of NAA/Cr, Cho/Cr, and mI/Cr ratios between the patients and the control group (all P>0.05). Our study suggested that there is no permanent neuronal damage in patients with breath-holding spells. This result confirms the previous studies, which reported no permanent neuronal damage in patients with breath-holding spells. Keywords: brain metabolite, children, breath holding, magnetic resonance spectroscopy
format	article
author	Calik M Sen Dokumaci D Sarikaya S Demir M Isik I Kazanasmaz H Kaya C Kandemir H
author_facet	Calik M Sen Dokumaci D Sarikaya S Demir M Isik I Kazanasmaz H Kaya C Kandemir H
author_sort	Calik M
title	Brain metabolite values in children with breath-holding spells
title_short	Brain metabolite values in children with breath-holding spells
title_full	Brain metabolite values in children with breath-holding spells
title_fullStr	Brain metabolite values in children with breath-holding spells
title_full_unstemmed	Brain metabolite values in children with breath-holding spells
title_sort	brain metabolite values in children with breath-holding spells
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/547797fac96c4656b09089d4fb738a3e
work_keys_str_mv	AT calikm brainmetabolitevaluesinchildrenwithbreathholdingspells AT sendokumacid brainmetabolitevaluesinchildrenwithbreathholdingspells AT sarikayas brainmetabolitevaluesinchildrenwithbreathholdingspells AT demirm brainmetabolitevaluesinchildrenwithbreathholdingspells AT isiki brainmetabolitevaluesinchildrenwithbreathholdingspells AT kazanasmazh brainmetabolitevaluesinchildrenwithbreathholdingspells AT kayac brainmetabolitevaluesinchildrenwithbreathholdingspells AT kandemirh brainmetabolitevaluesinchildrenwithbreathholdingspells
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Brain metabolite values in children with breath-holding spells

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