Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

ABSTRACT Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal a...

Full description

Saved in:
Bibliographic Details
Main Authors: David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
bNAbs
infant-T/F virus
mother-to-child transmission
HIV
neutralization
MTCT
Microbiology
QR1-502
Online Access:https://doaj.org/article/547a9acf953c4c8cac9d486936a9784c
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/547a9acf953c4c8cac9d486936a9784c

Similar Items