Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

ABSTRACT Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal a...

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Autores principales: David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
bNAbs
infant-T/F virus
mother-to-child transmission
HIV
neutralization
MTCT
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/547a9acf953c4c8cac9d486936a9784c
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