Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study

Background Therapeutic advances have reduced cardiovascular death rates in people with cardiovascular diseases (CVD). We aimed to define the rates of cardiovascular and noncardiovascular death in people with specified CVDs or accruing cardiovascular multimorbidity. Methods and Results We studied 493...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael Drozd, Mar Pujades‐Rodriguez, Fei Sun, Kevin N. Franks, Patrick J. Lillie, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cancer cardiovascular death infection Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/547f174350f64fc2a87e91a3f07c8ddd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:547f174350f64fc2a87e91a3f07c8ddd
record_format	dspace
spelling	oai:doaj.org-article:547f174350f64fc2a87e91a3f07c8ddd2021-11-16T10:22:44ZCauses of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study10.1161/JAHA.121.0231882047-9980https://doaj.org/article/547f174350f64fc2a87e91a3f07c8ddd2021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.023188https://doaj.org/toc/2047-9980Background Therapeutic advances have reduced cardiovascular death rates in people with cardiovascular diseases (CVD). We aimed to define the rates of cardiovascular and noncardiovascular death in people with specified CVDs or accruing cardiovascular multimorbidity. Methods and Results We studied 493 280 UK residents enrolled in the UK Biobank cohort study. The proportion of deaths attributed to cardiovascular, cancer, infection, or other causes were calculated in groups defined by 9 distinct self‐reported CVDs at baseline, or by the number of these CVDs at baseline. Poisson regression analyses were then used to define adjusted incidence rate ratios for these causes of death, accounting for sociodemographic factors and comorbidity. Of 27 729 deaths, 20.4% were primarily attributed to CVD, 53.6% to cancer, 5.0% to infection, and 21.0% to other causes. As cardiovascular multimorbidity increased, the proportion of cardiovascular and infection‐related deaths was greater, contrasting with cancer and other deaths. Compared with people without CVD, those with 3 or more CVDs experienced adjusted incidence rate ratios of 7.0 (6.2–7.8) for cardiovascular death, 4.4 (3.4–5.6) for infection death, 1.5 (1.4–1.7) for cancer death, and 2.0 (1.7–2.4) for other causes of death. There was substantial heterogeneity in causes of death, both in terms of crude proportions and adjusted incidence rate ratios, among the 9 studied baseline CVDs. Conclusions Noncardiovascular death is common in people with CVD, although its contribution varies widely between people with different CVDs. Holistic and personalized care are likely to be important tools for continuing to improve outcomes in people with CVD.Michael DrozdMar Pujades‐RodriguezFei SunKevin N. FranksPatrick J. LillieKlaus K. WitteMark T. KearneyRichard M. CubbonWileyarticlecancercardiovasculardeathinfectionDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer cardiovascular death infection Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cancer cardiovascular death infection Diseases of the circulatory (Cardiovascular) system RC666-701 Michael Drozd Mar Pujades‐Rodriguez Fei Sun Kevin N. Franks Patrick J. Lillie Klaus K. Witte Mark T. Kearney Richard M. Cubbon Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
description	Background Therapeutic advances have reduced cardiovascular death rates in people with cardiovascular diseases (CVD). We aimed to define the rates of cardiovascular and noncardiovascular death in people with specified CVDs or accruing cardiovascular multimorbidity. Methods and Results We studied 493 280 UK residents enrolled in the UK Biobank cohort study. The proportion of deaths attributed to cardiovascular, cancer, infection, or other causes were calculated in groups defined by 9 distinct self‐reported CVDs at baseline, or by the number of these CVDs at baseline. Poisson regression analyses were then used to define adjusted incidence rate ratios for these causes of death, accounting for sociodemographic factors and comorbidity. Of 27 729 deaths, 20.4% were primarily attributed to CVD, 53.6% to cancer, 5.0% to infection, and 21.0% to other causes. As cardiovascular multimorbidity increased, the proportion of cardiovascular and infection‐related deaths was greater, contrasting with cancer and other deaths. Compared with people without CVD, those with 3 or more CVDs experienced adjusted incidence rate ratios of 7.0 (6.2–7.8) for cardiovascular death, 4.4 (3.4–5.6) for infection death, 1.5 (1.4–1.7) for cancer death, and 2.0 (1.7–2.4) for other causes of death. There was substantial heterogeneity in causes of death, both in terms of crude proportions and adjusted incidence rate ratios, among the 9 studied baseline CVDs. Conclusions Noncardiovascular death is common in people with CVD, although its contribution varies widely between people with different CVDs. Holistic and personalized care are likely to be important tools for continuing to improve outcomes in people with CVD.
format	article
author	Michael Drozd Mar Pujades‐Rodriguez Fei Sun Kevin N. Franks Patrick J. Lillie Klaus K. Witte Mark T. Kearney Richard M. Cubbon
author_facet	Michael Drozd Mar Pujades‐Rodriguez Fei Sun Kevin N. Franks Patrick J. Lillie Klaus K. Witte Mark T. Kearney Richard M. Cubbon
author_sort	Michael Drozd
title	Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
title_short	Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
title_full	Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
title_fullStr	Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
title_full_unstemmed	Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study
title_sort	causes of death in people with cardiovascular disease: a uk biobank cohort study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/547f174350f64fc2a87e91a3f07c8ddd
work_keys_str_mv	AT michaeldrozd causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT marpujadesrodriguez causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT feisun causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT kevinnfranks causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT patrickjlillie causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT klauskwitte causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT marktkearney causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy AT richardmcubbon causesofdeathinpeoplewithcardiovasculardiseaseaukbiobankcohortstudy
_version_	1718426545711742976

Causes of Death in People With Cardiovascular Disease: A UK Biobank Cohort Study

Ejemplares similares