Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.

<h4>Objective</h4>A major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timin...

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Autores principales:	Zhe-rong Xu, Zhong-ju Tan, Qin Zhang, Qi-feng Gui, Yun-mei Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5481a839bedc4618aea26b6d3b5e559a
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spelling	oai:doaj.org-article:5481a839bedc4618aea26b6d3b5e559a2021-11-25T05:58:34ZClinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.1932-620310.1371/journal.pone.0109141https://doaj.org/article/5481a839bedc4618aea26b6d3b5e559a2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109141https://doaj.org/toc/1932-6203<h4>Objective</h4>A major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timing of intervention, and physical exercise to improve muscle loss unclear as finding from studies investigating this issue have been inconsistent. We have performed a systematic review and meta-analysis to assess the ability of protein or amino acid supplementation to augment lean body mass or strength of leg muscles in elderly patients.<h4>Methods</h4>Nine studies met the inclusion criteria of being a prospective comparative study or randomized controlled trial (RCT) that compared the efficacy of an amino acid or protein supplement intervention with that of a placebo in elderly people (≥ 65 years) for the improvement of lean body mass (LBM), leg muscle strength or reduction associated with sarcopenia.<h4>Results</h4>The overall difference in mean change from baseline to the end of study in LBM between the treatment and placebo groups was 0.34 kg which was not significant (P = 0.386). The overall differences in mean change from baseline in double leg press and leg extension were 2.14 kg (P = 0.748) and 2.28 kg (P = 0.265), respectively, between the treatment group and the placebo group.<h4>Conclusions</h4>These results indicate that amino acid/protein supplements did not increase lean body mass gain and muscle strength significantly more than placebo in a diverse elderly population.Zhe-rong XuZhong-ju TanQin ZhangQi-feng GuiYun-mei YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e109141 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhe-rong Xu Zhong-ju Tan Qin Zhang Qi-feng Gui Yun-mei Yang Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
description	<h4>Objective</h4>A major reason for the loss of mobility in elderly people is the gradual loss of lean body mass known as sarcopenia. Sarcopenia is associated with a lower quality of life and higher healthcare costs. The benefit of strategies that include nutritional intervention, timing of intervention, and physical exercise to improve muscle loss unclear as finding from studies investigating this issue have been inconsistent. We have performed a systematic review and meta-analysis to assess the ability of protein or amino acid supplementation to augment lean body mass or strength of leg muscles in elderly patients.<h4>Methods</h4>Nine studies met the inclusion criteria of being a prospective comparative study or randomized controlled trial (RCT) that compared the efficacy of an amino acid or protein supplement intervention with that of a placebo in elderly people (≥ 65 years) for the improvement of lean body mass (LBM), leg muscle strength or reduction associated with sarcopenia.<h4>Results</h4>The overall difference in mean change from baseline to the end of study in LBM between the treatment and placebo groups was 0.34 kg which was not significant (P = 0.386). The overall differences in mean change from baseline in double leg press and leg extension were 2.14 kg (P = 0.748) and 2.28 kg (P = 0.265), respectively, between the treatment group and the placebo group.<h4>Conclusions</h4>These results indicate that amino acid/protein supplements did not increase lean body mass gain and muscle strength significantly more than placebo in a diverse elderly population.
format	article
author	Zhe-rong Xu Zhong-ju Tan Qin Zhang Qi-feng Gui Yun-mei Yang
author_facet	Zhe-rong Xu Zhong-ju Tan Qin Zhang Qi-feng Gui Yun-mei Yang
author_sort	Zhe-rong Xu
title	Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
title_short	Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
title_full	Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
title_fullStr	Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
title_full_unstemmed	Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
title_sort	clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5481a839bedc4618aea26b6d3b5e559a
work_keys_str_mv	AT zherongxu clinicaleffectivenessofproteinandaminoacidsupplementationonbuildingmusclemassinelderlypeopleametaanalysis AT zhongjutan clinicaleffectivenessofproteinandaminoacidsupplementationonbuildingmusclemassinelderlypeopleametaanalysis AT qinzhang clinicaleffectivenessofproteinandaminoacidsupplementationonbuildingmusclemassinelderlypeopleametaanalysis AT qifenggui clinicaleffectivenessofproteinandaminoacidsupplementationonbuildingmusclemassinelderlypeopleametaanalysis AT yunmeiyang clinicaleffectivenessofproteinandaminoacidsupplementationonbuildingmusclemassinelderlypeopleametaanalysis
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Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis.

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