EBV Positive Aggressive NK-Cell Leukemia

Introduction: Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells associated with poor overall survival. Significant variation in the morphology of the neoplastic cells on peripheral smear makes it diagnostically challenging. Case Report: A 54-year...

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Autores principales:	Ankitha Hebbar, Ruchee Khanna, Sushma Belurkar, Shubham Varshney, Aradhana Harrison, Sindhura Lakshmi KL
Formato:	article
Lenguaje:	EN
Publicado:	Light House Polyclinic Mangalore 2021
Materias:	ebv ankl flow cytometry Medicine R
Acceso en línea:	https://doaj.org/article/54841631a11f47c88975c6c41876367f
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spelling	oai:doaj.org-article:54841631a11f47c88975c6c41876367f2021-11-12T08:57:21ZEBV Positive Aggressive NK-Cell Leukemia0972-5997https://doaj.org/article/54841631a11f47c88975c6c41876367f2021-10-01T00:00:00Zhttps://www.ojhas.org/issue79/2021-3-14.htmlhttps://doaj.org/toc/0972-5997Introduction: Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells associated with poor overall survival. Significant variation in the morphology of the neoplastic cells on peripheral smear makes it diagnostically challenging. Case Report: A 54-year old male presented with fever and icterus since 15 days. Peripheral smear showed 64% abnormal cells. Flow cytometry showed positivity of abnormal cells for CD2, CD3, CD7, CD56 and HLA-DR. EBV DNA tested positive by Real-time PCR. A final diagnosis of aggressive NK-cell leukemia was made. Conclusion: The diagnosis of aggressive NK cell leukemia is usually delayed due to the non-specific clinical symptoms and varied morphology. However, early recognition and diagnosis of the disease is important, as the introduction of combined chemotherapy and allogenic hematopoietic stem cell transplantation can help achieve complete response and potential cure.Ankitha HebbarRuchee KhannaSushma BelurkarShubham VarshneyAradhana HarrisonSindhura Lakshmi KLLight House Polyclinic Mangalore articleebvanklflow cytometryMedicineRENOnline Journal of Health & Allied Sciences, Vol 20, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ebv ankl flow cytometry Medicine R
spellingShingle	ebv ankl flow cytometry Medicine R Ankitha Hebbar Ruchee Khanna Sushma Belurkar Shubham Varshney Aradhana Harrison Sindhura Lakshmi KL EBV Positive Aggressive NK-Cell Leukemia
description	Introduction: Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells associated with poor overall survival. Significant variation in the morphology of the neoplastic cells on peripheral smear makes it diagnostically challenging. Case Report: A 54-year old male presented with fever and icterus since 15 days. Peripheral smear showed 64% abnormal cells. Flow cytometry showed positivity of abnormal cells for CD2, CD3, CD7, CD56 and HLA-DR. EBV DNA tested positive by Real-time PCR. A final diagnosis of aggressive NK-cell leukemia was made. Conclusion: The diagnosis of aggressive NK cell leukemia is usually delayed due to the non-specific clinical symptoms and varied morphology. However, early recognition and diagnosis of the disease is important, as the introduction of combined chemotherapy and allogenic hematopoietic stem cell transplantation can help achieve complete response and potential cure.
format	article
author	Ankitha Hebbar Ruchee Khanna Sushma Belurkar Shubham Varshney Aradhana Harrison Sindhura Lakshmi KL
author_facet	Ankitha Hebbar Ruchee Khanna Sushma Belurkar Shubham Varshney Aradhana Harrison Sindhura Lakshmi KL
author_sort	Ankitha Hebbar
title	EBV Positive Aggressive NK-Cell Leukemia
title_short	EBV Positive Aggressive NK-Cell Leukemia
title_full	EBV Positive Aggressive NK-Cell Leukemia
title_fullStr	EBV Positive Aggressive NK-Cell Leukemia
title_full_unstemmed	EBV Positive Aggressive NK-Cell Leukemia
title_sort	ebv positive aggressive nk-cell leukemia
publisher	Light House Polyclinic Mangalore
publishDate	2021
url	https://doaj.org/article/54841631a11f47c88975c6c41876367f
work_keys_str_mv	AT ankithahebbar ebvpositiveaggressivenkcellleukemia AT rucheekhanna ebvpositiveaggressivenkcellleukemia AT sushmabelurkar ebvpositiveaggressivenkcellleukemia AT shubhamvarshney ebvpositiveaggressivenkcellleukemia AT aradhanaharrison ebvpositiveaggressivenkcellleukemia AT sindhuralakshmikl ebvpositiveaggressivenkcellleukemia
_version_	1718431048210055168

EBV Positive Aggressive NK-Cell Leukemia

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