Outcomes of controlled human malaria infection after BCG vaccination

Outcomes of controlled human malaria infection after BCG vaccination

Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activa...

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Autores principales: Jona Walk, L. Charlotte J. de Bree, Wouter Graumans, Rianne Stoter, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Karina Teelen, Cornelus C. Hermsen, Rob J. W. Arts, Marije C. Behet, Farid Keramati, Simone J. C. F. M. Moorlag, Annie S. P. Yang, Reinout van Crevel, Peter Aaby, Quirijn de Mast, André J. A. M. van der Ven, Christine Stabell Benn, Mihai G. Netea, Robert W. Sauerwein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/548440850a244fa5947c578ae0771c61
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Sumario:Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.

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