Outcomes of controlled human malaria infection after BCG vaccination

Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activa...

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Autores principales: Jona Walk, L. Charlotte J. de Bree, Wouter Graumans, Rianne Stoter, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Karina Teelen, Cornelus C. Hermsen, Rob J. W. Arts, Marije C. Behet, Farid Keramati, Simone J. C. F. M. Moorlag, Annie S. P. Yang, Reinout van Crevel, Peter Aaby, Quirijn de Mast, André J. A. M. van der Ven, Christine Stabell Benn, Mihai G. Netea, Robert W. Sauerwein
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/548440850a244fa5947c578ae0771c61
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spelling oai:doaj.org-article:548440850a244fa5947c578ae0771c612021-12-02T16:58:25ZOutcomes of controlled human malaria infection after BCG vaccination10.1038/s41467-019-08659-32041-1723https://doaj.org/article/548440850a244fa5947c578ae0771c612019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08659-3https://doaj.org/toc/2041-1723Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.Jona WalkL. Charlotte J. de BreeWouter GraumansRianne StoterGeert-Jan van GemertMarga van de Vegte-BolmerKarina TeelenCornelus C. HermsenRob J. W. ArtsMarije C. BehetFarid KeramatiSimone J. C. F. M. MoorlagAnnie S. P. YangReinout van CrevelPeter AabyQuirijn de MastAndré J. A. M. van der VenChristine Stabell BennMihai G. NeteaRobert W. SauerweinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jona Walk
L. Charlotte J. de Bree
Wouter Graumans
Rianne Stoter
Geert-Jan van Gemert
Marga van de Vegte-Bolmer
Karina Teelen
Cornelus C. Hermsen
Rob J. W. Arts
Marije C. Behet
Farid Keramati
Simone J. C. F. M. Moorlag
Annie S. P. Yang
Reinout van Crevel
Peter Aaby
Quirijn de Mast
André J. A. M. van der Ven
Christine Stabell Benn
Mihai G. Netea
Robert W. Sauerwein
Outcomes of controlled human malaria infection after BCG vaccination
description Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.
format article
author Jona Walk
L. Charlotte J. de Bree
Wouter Graumans
Rianne Stoter
Geert-Jan van Gemert
Marga van de Vegte-Bolmer
Karina Teelen
Cornelus C. Hermsen
Rob J. W. Arts
Marije C. Behet
Farid Keramati
Simone J. C. F. M. Moorlag
Annie S. P. Yang
Reinout van Crevel
Peter Aaby
Quirijn de Mast
André J. A. M. van der Ven
Christine Stabell Benn
Mihai G. Netea
Robert W. Sauerwein
author_facet Jona Walk
L. Charlotte J. de Bree
Wouter Graumans
Rianne Stoter
Geert-Jan van Gemert
Marga van de Vegte-Bolmer
Karina Teelen
Cornelus C. Hermsen
Rob J. W. Arts
Marije C. Behet
Farid Keramati
Simone J. C. F. M. Moorlag
Annie S. P. Yang
Reinout van Crevel
Peter Aaby
Quirijn de Mast
André J. A. M. van der Ven
Christine Stabell Benn
Mihai G. Netea
Robert W. Sauerwein
author_sort Jona Walk
title Outcomes of controlled human malaria infection after BCG vaccination
title_short Outcomes of controlled human malaria infection after BCG vaccination
title_full Outcomes of controlled human malaria infection after BCG vaccination
title_fullStr Outcomes of controlled human malaria infection after BCG vaccination
title_full_unstemmed Outcomes of controlled human malaria infection after BCG vaccination
title_sort outcomes of controlled human malaria infection after bcg vaccination
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/548440850a244fa5947c578ae0771c61
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