Outcomes of controlled human malaria infection after BCG vaccination
Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activa...
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Nature Portfolio
2019
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Acceso en línea: | https://doaj.org/article/548440850a244fa5947c578ae0771c61 |
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oai:doaj.org-article:548440850a244fa5947c578ae0771c612021-12-02T16:58:25ZOutcomes of controlled human malaria infection after BCG vaccination10.1038/s41467-019-08659-32041-1723https://doaj.org/article/548440850a244fa5947c578ae0771c612019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08659-3https://doaj.org/toc/2041-1723Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia.Jona WalkL. Charlotte J. de BreeWouter GraumansRianne StoterGeert-Jan van GemertMarga van de Vegte-BolmerKarina TeelenCornelus C. HermsenRob J. W. ArtsMarije C. BehetFarid KeramatiSimone J. C. F. M. MoorlagAnnie S. P. YangReinout van CrevelPeter AabyQuirijn de MastAndré J. A. M. van der VenChristine Stabell BennMihai G. NeteaRobert W. SauerweinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019) |
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Science Q Jona Walk L. Charlotte J. de Bree Wouter Graumans Rianne Stoter Geert-Jan van Gemert Marga van de Vegte-Bolmer Karina Teelen Cornelus C. Hermsen Rob J. W. Arts Marije C. Behet Farid Keramati Simone J. C. F. M. Moorlag Annie S. P. Yang Reinout van Crevel Peter Aaby Quirijn de Mast André J. A. M. van der Ven Christine Stabell Benn Mihai G. Netea Robert W. Sauerwein Outcomes of controlled human malaria infection after BCG vaccination |
description |
Immune activation induces long-term alterations of setpoints, impacting responses to subsequent unrelated stimuli. Here the authors show that volunteers vaccinated with BCG respond to controlled human malaria infection with increased clinical symptoms and an inverse correlation between immune activation markers and parasitemia. |
format |
article |
author |
Jona Walk L. Charlotte J. de Bree Wouter Graumans Rianne Stoter Geert-Jan van Gemert Marga van de Vegte-Bolmer Karina Teelen Cornelus C. Hermsen Rob J. W. Arts Marije C. Behet Farid Keramati Simone J. C. F. M. Moorlag Annie S. P. Yang Reinout van Crevel Peter Aaby Quirijn de Mast André J. A. M. van der Ven Christine Stabell Benn Mihai G. Netea Robert W. Sauerwein |
author_facet |
Jona Walk L. Charlotte J. de Bree Wouter Graumans Rianne Stoter Geert-Jan van Gemert Marga van de Vegte-Bolmer Karina Teelen Cornelus C. Hermsen Rob J. W. Arts Marije C. Behet Farid Keramati Simone J. C. F. M. Moorlag Annie S. P. Yang Reinout van Crevel Peter Aaby Quirijn de Mast André J. A. M. van der Ven Christine Stabell Benn Mihai G. Netea Robert W. Sauerwein |
author_sort |
Jona Walk |
title |
Outcomes of controlled human malaria infection after BCG vaccination |
title_short |
Outcomes of controlled human malaria infection after BCG vaccination |
title_full |
Outcomes of controlled human malaria infection after BCG vaccination |
title_fullStr |
Outcomes of controlled human malaria infection after BCG vaccination |
title_full_unstemmed |
Outcomes of controlled human malaria infection after BCG vaccination |
title_sort |
outcomes of controlled human malaria infection after bcg vaccination |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/548440850a244fa5947c578ae0771c61 |
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