Coupled evolution of transcription and mRNA degradation.

mRNA levels are determined by the balance between transcription and mRNA degradation, and while transcription has been extensively studied, very little is known regarding the regulation of mRNA degradation and its coordination with transcription. Here we examine the evolution of mRNA degradation rat...

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Autores principales:	Mally Dori-Bachash, Efrat Shema, Itay Tirosh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5488f68acbeb4f0ea5b8de4079fe0a5b
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id	oai:doaj.org-article:5488f68acbeb4f0ea5b8de4079fe0a5b
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spelling	oai:doaj.org-article:5488f68acbeb4f0ea5b8de4079fe0a5b2021-11-18T05:36:06ZCoupled evolution of transcription and mRNA degradation.1544-91731545-788510.1371/journal.pbio.1001106https://doaj.org/article/5488f68acbeb4f0ea5b8de4079fe0a5b2011-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21811398/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885mRNA levels are determined by the balance between transcription and mRNA degradation, and while transcription has been extensively studied, very little is known regarding the regulation of mRNA degradation and its coordination with transcription. Here we examine the evolution of mRNA degradation rates between two closely related yeast species. Surprisingly, we find that around half of the evolutionary changes in mRNA degradation were coupled to transcriptional changes that exert opposite effects on mRNA levels. Analysis of mRNA degradation rates in an interspecific hybrid further suggests that opposite evolutionary changes in transcription and in mRNA degradation are mechanistically coupled and were generated by the same individual mutations. Coupled changes are associated with divergence of two complexes that were previously implicated both in transcription and in mRNA degradation (Rpb4/7 and Ccr4-Not), as well as with sequence divergence of transcription factor binding motifs. These results suggest that an opposite coupling between the regulation of transcription and that of mRNA degradation has shaped the evolution of gene regulation in yeast.Mally Dori-BachashEfrat ShemaItay TiroshPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 9, Iss 7, p e1001106 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mally Dori-Bachash Efrat Shema Itay Tirosh Coupled evolution of transcription and mRNA degradation.
description	mRNA levels are determined by the balance between transcription and mRNA degradation, and while transcription has been extensively studied, very little is known regarding the regulation of mRNA degradation and its coordination with transcription. Here we examine the evolution of mRNA degradation rates between two closely related yeast species. Surprisingly, we find that around half of the evolutionary changes in mRNA degradation were coupled to transcriptional changes that exert opposite effects on mRNA levels. Analysis of mRNA degradation rates in an interspecific hybrid further suggests that opposite evolutionary changes in transcription and in mRNA degradation are mechanistically coupled and were generated by the same individual mutations. Coupled changes are associated with divergence of two complexes that were previously implicated both in transcription and in mRNA degradation (Rpb4/7 and Ccr4-Not), as well as with sequence divergence of transcription factor binding motifs. These results suggest that an opposite coupling between the regulation of transcription and that of mRNA degradation has shaped the evolution of gene regulation in yeast.
format	article
author	Mally Dori-Bachash Efrat Shema Itay Tirosh
author_facet	Mally Dori-Bachash Efrat Shema Itay Tirosh
author_sort	Mally Dori-Bachash
title	Coupled evolution of transcription and mRNA degradation.
title_short	Coupled evolution of transcription and mRNA degradation.
title_full	Coupled evolution of transcription and mRNA degradation.
title_fullStr	Coupled evolution of transcription and mRNA degradation.
title_full_unstemmed	Coupled evolution of transcription and mRNA degradation.
title_sort	coupled evolution of transcription and mrna degradation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5488f68acbeb4f0ea5b8de4079fe0a5b
work_keys_str_mv	AT mallydoribachash coupledevolutionoftranscriptionandmrnadegradation AT efratshema coupledevolutionoftranscriptionandmrnadegradation AT itaytirosh coupledevolutionoftranscriptionandmrnadegradation
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Coupled evolution of transcription and mRNA degradation.

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