Expanding the limits of the second genetic code with ribozymes

Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more effectively predict the incorporation of new monomers into peptides.

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Autores principales:	Joongoo Lee, Kenneth E. Schwieter, Andrew M. Watkins, Do Soon Kim, Hao Yu, Kevin J. Schwarz, Jongdoo Lim, Jaime Coronado, Michelle Byrom, Eric V. Anslyn, Andrew D. Ellington, Jeffrey S. Moore, Michael C. Jewett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/548c054981ad4d0a9ebff922fc32ffbd
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spelling	oai:doaj.org-article:548c054981ad4d0a9ebff922fc32ffbd2021-12-02T17:01:38ZExpanding the limits of the second genetic code with ribozymes10.1038/s41467-019-12916-w2041-1723https://doaj.org/article/548c054981ad4d0a9ebff922fc32ffbd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12916-whttps://doaj.org/toc/2041-1723Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more effectively predict the incorporation of new monomers into peptides.Joongoo LeeKenneth E. SchwieterAndrew M. WatkinsDo Soon KimHao YuKevin J. SchwarzJongdoo LimJaime CoronadoMichelle ByromEric V. AnslynAndrew D. EllingtonJeffrey S. MooreMichael C. JewettNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joongoo Lee Kenneth E. Schwieter Andrew M. Watkins Do Soon Kim Hao Yu Kevin J. Schwarz Jongdoo Lim Jaime Coronado Michelle Byrom Eric V. Anslyn Andrew D. Ellington Jeffrey S. Moore Michael C. Jewett Expanding the limits of the second genetic code with ribozymes
description	Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more effectively predict the incorporation of new monomers into peptides.
format	article
author	Joongoo Lee Kenneth E. Schwieter Andrew M. Watkins Do Soon Kim Hao Yu Kevin J. Schwarz Jongdoo Lim Jaime Coronado Michelle Byrom Eric V. Anslyn Andrew D. Ellington Jeffrey S. Moore Michael C. Jewett
author_facet	Joongoo Lee Kenneth E. Schwieter Andrew M. Watkins Do Soon Kim Hao Yu Kevin J. Schwarz Jongdoo Lim Jaime Coronado Michelle Byrom Eric V. Anslyn Andrew D. Ellington Jeffrey S. Moore Michael C. Jewett
author_sort	Joongoo Lee
title	Expanding the limits of the second genetic code with ribozymes
title_short	Expanding the limits of the second genetic code with ribozymes
title_full	Expanding the limits of the second genetic code with ribozymes
title_fullStr	Expanding the limits of the second genetic code with ribozymes
title_full_unstemmed	Expanding the limits of the second genetic code with ribozymes
title_sort	expanding the limits of the second genetic code with ribozymes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/548c054981ad4d0a9ebff922fc32ffbd
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Expanding the limits of the second genetic code with ribozymes

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