Expanding the limits of the second genetic code with ribozymes
Flexizymes have been used to expand the scope of chemical substrates for ribosome-directed polymerization in vitro. Here the authors deduce design rules of Flexizyme-mediated tRNA acylation that more effectively predict the incorporation of new monomers into peptides.
Guardado en:
Autores principales: | Joongoo Lee, Kenneth E. Schwieter, Andrew M. Watkins, Do Soon Kim, Hao Yu, Kevin J. Schwarz, Jongdoo Lim, Jaime Coronado, Michelle Byrom, Eric V. Anslyn, Andrew D. Ellington, Jeffrey S. Moore, Michael C. Jewett |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/548c054981ad4d0a9ebff922fc32ffbd |
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