Concordant association validates MGMT methylation and protein expression as favorable prognostic factors in glioma patients on alkylating chemotherapy (Temozolomide)
Abstract O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and its subsequent loss of protein expression has been identified to have a variable impact on clinical outcome of glioma patients indicated for chemotherapy with alkylating agents (Temozolomide). This study investigated met...
Enregistré dans:
Auteurs principaux: | Arshad A. Pandith, Iqbal Qasim, Wani Zahoor, Parveen Shah, Abdul R. Bhat, Dheera Sanadhya, Zafar A. Shah, Niyaz A. Naikoo |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/548c0cac4dd5430d8f1be989d8f19c25 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Advances in the management of glioblastoma: the role of temozolomide and MGMT testing
par: Thomas RP, et autres
Publié: (2012) -
A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
par: Xiaoyue Chen, et autres
Publié: (2018) -
Lack of Benefit of Extending Temozolomide Treatment in Patients with High Vascular Glioblastoma with Methylated <i>MGMT</i>
par: María del Mar Álvarez-Torres, et autres
Publié: (2021) -
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.
par: Simone Kreth, et autres
Publié: (2011) -
MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
par: Barbara Oldrini, et autres
Publié: (2020)