Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic...

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Autores principales:	Ke Zhu, Yumei Lai, Huiling Cao, Xiaochun Bai, Chuanju Liu, Qinnan Yan, Liting Ma, Di Chen, Giedrius Kanaporis, Junqi Wang, Luyuan Li, Tao Cheng, Yong Wang, Chuanyue Wu, Guozhi Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/548e9c8e7d274d1f95a9ccdc09d4cf7f
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spelling	oai:doaj.org-article:548e9c8e7d274d1f95a9ccdc09d4cf7f2021-12-02T15:37:13ZKindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice10.1038/s41467-019-14186-y2041-1723https://doaj.org/article/548e9c8e7d274d1f95a9ccdc09d4cf7f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14186-yhttps://doaj.org/toc/2041-1723Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.Ke ZhuYumei LaiHuiling CaoXiaochun BaiChuanju LiuQinnan YanLiting MaDi ChenGiedrius KanaporisJunqi WangLuyuan LiTao ChengYong WangChuanyue WuGuozhi XiaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
description	Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic beta cells.
format	article
author	Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao
author_facet	Ke Zhu Yumei Lai Huiling Cao Xiaochun Bai Chuanju Liu Qinnan Yan Liting Ma Di Chen Giedrius Kanaporis Junqi Wang Luyuan Li Tao Cheng Yong Wang Chuanyue Wu Guozhi Xiao
author_sort	Ke Zhu
title	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_short	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_full	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_fullStr	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_full_unstemmed	Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
title_sort	kindlin-2 modulates mafa and β-catenin expression to regulate β-cell function and mass in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/548e9c8e7d274d1f95a9ccdc09d4cf7f
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Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

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