Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma

Abstract Choroidal microvasculature dropout (CMvD) implies compromised optic nerve head perfusion in glaucoma patients. However, there are conflicting findings whether office-hour systemic blood pressure (BP) is related to the presence of CMvD. The present study investigated which systemic BP parame...

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Autores principales:	Joong Won Shin, Youn Hye Jo, Min Kyung Song, Hun Jae Won, Michael S. Kook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54957ca02c5b4ba5808d821833472dcd
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spelling	oai:doaj.org-article:54957ca02c5b4ba5808d821833472dcd2021-12-02T15:13:10ZNocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma10.1038/s41598-020-80705-32045-2322https://doaj.org/article/54957ca02c5b4ba5808d821833472dcd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80705-3https://doaj.org/toc/2045-2322Abstract Choroidal microvasculature dropout (CMvD) implies compromised optic nerve head perfusion in glaucoma patients. However, there are conflicting findings whether office-hour systemic blood pressure (BP) is related to the presence of CMvD. The present study investigated which systemic BP parameters, derived from 24-h ambulatory BP monitoring (ABPM), are associated with CMvD as assessed by optical coherence tomography angiography (OCT-A) in normal-tension glaucoma (NTG). This study included 88 eyes of 88 NTG patients who underwent 24-h ABPM and OCT-A imaging. Various systemic BP parameters associated with the presence of CMvD were evaluated using logistic regression analyses. CMvD was detected in 38 NTG eyes (43.2%). NTG eyes with CMvD had nighttime diastolic BP (DBP) dip of greater magnitude and longer duration than eyes without CMvD. In multivariate logistic regression, worse VF mean deviation (MD) (odds ratio [OR] 0.786; P = 0.001), greater nighttime DBP dip “%” (OR 1.051; P = 0.034), and higher daytime peak IOP (OR 1.459; P = 0.013) were significantly associated with the presence of CMvD. Based on our findings that the eyes with CMvD are closely associated with having nighttime DBP dip, NTG patients with CMvD should be recommended to undergo 24-h ABPM.Joong Won ShinYoun Hye JoMin Kyung SongHun Jae WonMichael S. KookNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joong Won Shin Youn Hye Jo Min Kyung Song Hun Jae Won Michael S. Kook Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
description	Abstract Choroidal microvasculature dropout (CMvD) implies compromised optic nerve head perfusion in glaucoma patients. However, there are conflicting findings whether office-hour systemic blood pressure (BP) is related to the presence of CMvD. The present study investigated which systemic BP parameters, derived from 24-h ambulatory BP monitoring (ABPM), are associated with CMvD as assessed by optical coherence tomography angiography (OCT-A) in normal-tension glaucoma (NTG). This study included 88 eyes of 88 NTG patients who underwent 24-h ABPM and OCT-A imaging. Various systemic BP parameters associated with the presence of CMvD were evaluated using logistic regression analyses. CMvD was detected in 38 NTG eyes (43.2%). NTG eyes with CMvD had nighttime diastolic BP (DBP) dip of greater magnitude and longer duration than eyes without CMvD. In multivariate logistic regression, worse VF mean deviation (MD) (odds ratio [OR] 0.786; P = 0.001), greater nighttime DBP dip “%” (OR 1.051; P = 0.034), and higher daytime peak IOP (OR 1.459; P = 0.013) were significantly associated with the presence of CMvD. Based on our findings that the eyes with CMvD are closely associated with having nighttime DBP dip, NTG patients with CMvD should be recommended to undergo 24-h ABPM.
format	article
author	Joong Won Shin Youn Hye Jo Min Kyung Song Hun Jae Won Michael S. Kook
author_facet	Joong Won Shin Youn Hye Jo Min Kyung Song Hun Jae Won Michael S. Kook
author_sort	Joong Won Shin
title	Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
title_short	Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
title_full	Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
title_fullStr	Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
title_full_unstemmed	Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
title_sort	nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54957ca02c5b4ba5808d821833472dcd
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Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma

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