Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases

TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. Using computational electrophysiology simulations, the authors identify the main ion-conductive state of TMEM16 lipid scramblases and find that lipid...

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Autores principales:	Andrei Y. Kostritskii, Jan-Philipp Machtens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54969e45e88840bd82451cbf4c527254
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spelling	oai:doaj.org-article:54969e45e88840bd82451cbf4c5272542021-12-02T15:55:20ZMolecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases10.1038/s41467-021-22724-w2041-1723https://doaj.org/article/54969e45e88840bd82451cbf4c5272542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22724-whttps://doaj.org/toc/2041-1723TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. Using computational electrophysiology simulations, the authors identify the main ion-conductive state of TMEM16 lipid scramblases and find that lipid headgroups modulate ion permeability and regulate ion selectivity of TMEM16 proteolipidic pores.Andrei Y. KostritskiiJan-Philipp MachtensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrei Y. Kostritskii Jan-Philipp Machtens Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
description	TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. Using computational electrophysiology simulations, the authors identify the main ion-conductive state of TMEM16 lipid scramblases and find that lipid headgroups modulate ion permeability and regulate ion selectivity of TMEM16 proteolipidic pores.
format	article
author	Andrei Y. Kostritskii Jan-Philipp Machtens
author_facet	Andrei Y. Kostritskii Jan-Philipp Machtens
author_sort	Andrei Y. Kostritskii
title	Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
title_short	Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
title_full	Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
title_fullStr	Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
title_full_unstemmed	Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases
title_sort	molecular mechanisms of ion conduction and ion selectivity in tmem16 lipid scramblases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54969e45e88840bd82451cbf4c527254
work_keys_str_mv	AT andreiykostritskii molecularmechanismsofionconductionandionselectivityintmem16lipidscramblases AT janphilippmachtens molecularmechanismsofionconductionandionselectivityintmem16lipidscramblases
_version_	1718385391208235008

Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases

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