The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2.

<h4>Background</h4>The human immunodeficiency virus type 1 (HIV-1) p17 is a matrix protein involved in virus life's cycle. CXCR2 and Syndecan-2, the two major coreceptors for the p17 protein, are expressed in hepatic stellate cells (HSCs), a key cell type involved in matrix depositi...

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Main Authors: Barbara Renga, Daniela Francisci, Elisabetta Schiaroli, Adriana Carino, Sabrina Cipriani, Claudio D'Amore, Angelo Sidoni, Rachele Del Sordo, Ivana Ferri, Monica Lucattelli, Benedetta Lunghi, Franco Baldelli, Stefano Fiorucci
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/5497e44e65cd497781d6ea41bc9c47de
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