Roles of Long Non-coding RNAs in the Development of Chronic Pain

Chronic pain, a severe public health issue, affects the quality of life of patients and results in a major socioeconomic burden. Only limited drug treatments for chronic pain are available, and they have insufficient efficacy. Recent studies have found that the expression of long non-coding RNAs (ln...

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Autores principales:	Zheng Li, Xiongjuan Li, Wenling Jian, Qingsheng Xue, Zhiheng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	long non-coding RNA chronic neuropathic pain chronic cancer-related pain dorsal root ganglion spinal cord Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/54984592120047e094de2a499bdf543c
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spelling	oai:doaj.org-article:54984592120047e094de2a499bdf543c2021-11-30T12:23:20ZRoles of Long Non-coding RNAs in the Development of Chronic Pain1662-509910.3389/fnmol.2021.760964https://doaj.org/article/54984592120047e094de2a499bdf543c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.760964/fullhttps://doaj.org/toc/1662-5099Chronic pain, a severe public health issue, affects the quality of life of patients and results in a major socioeconomic burden. Only limited drug treatments for chronic pain are available, and they have insufficient efficacy. Recent studies have found that the expression of long non-coding RNAs (lncRNAs) is dysregulated in various chronic pain models, including chronic neuropathic pain, chronic inflammatory pain, and chronic cancer-related pain. Studies have also explored the effect of these dysregulated lncRNAs on the activation of microRNAs, inflammatory cytokines, and so on. These mechanisms have been widely demonstrated to play a critical role in the development of chronic pain. The findings of these studies indicate the significant roles of dysregulated lncRNAs in chronic pain in the dorsal root ganglion and spinal cord, following peripheral or central nerve lesions. This review summarizes the mechanism underlying the abnormal expression of lncRNAs in the development of chronic pain induced by peripheral nerve injury, diabetic neuropathy, inflammatory response, trigeminal neuralgia, spinal cord injury, cancer metastasis, and other conditions. Understanding the effect of lncRNAs may provide a novel insight that targeting lncRNAs could be a potential candidate for therapeutic intervention in chronic pain.Zheng LiZheng LiXiongjuan LiXiongjuan LiWenling JianWenling JianQingsheng XueZhiheng LiuZhiheng LiuFrontiers Media S.A.articlelong non-coding RNAchronic neuropathic painchronic cancer-related paindorsal root ganglionspinal cordNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	long non-coding RNA chronic neuropathic pain chronic cancer-related pain dorsal root ganglion spinal cord Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	long non-coding RNA chronic neuropathic pain chronic cancer-related pain dorsal root ganglion spinal cord Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zheng Li Zheng Li Xiongjuan Li Xiongjuan Li Wenling Jian Wenling Jian Qingsheng Xue Zhiheng Liu Zhiheng Liu Roles of Long Non-coding RNAs in the Development of Chronic Pain
description	Chronic pain, a severe public health issue, affects the quality of life of patients and results in a major socioeconomic burden. Only limited drug treatments for chronic pain are available, and they have insufficient efficacy. Recent studies have found that the expression of long non-coding RNAs (lncRNAs) is dysregulated in various chronic pain models, including chronic neuropathic pain, chronic inflammatory pain, and chronic cancer-related pain. Studies have also explored the effect of these dysregulated lncRNAs on the activation of microRNAs, inflammatory cytokines, and so on. These mechanisms have been widely demonstrated to play a critical role in the development of chronic pain. The findings of these studies indicate the significant roles of dysregulated lncRNAs in chronic pain in the dorsal root ganglion and spinal cord, following peripheral or central nerve lesions. This review summarizes the mechanism underlying the abnormal expression of lncRNAs in the development of chronic pain induced by peripheral nerve injury, diabetic neuropathy, inflammatory response, trigeminal neuralgia, spinal cord injury, cancer metastasis, and other conditions. Understanding the effect of lncRNAs may provide a novel insight that targeting lncRNAs could be a potential candidate for therapeutic intervention in chronic pain.
format	article
author	Zheng Li Zheng Li Xiongjuan Li Xiongjuan Li Wenling Jian Wenling Jian Qingsheng Xue Zhiheng Liu Zhiheng Liu
author_facet	Zheng Li Zheng Li Xiongjuan Li Xiongjuan Li Wenling Jian Wenling Jian Qingsheng Xue Zhiheng Liu Zhiheng Liu
author_sort	Zheng Li
title	Roles of Long Non-coding RNAs in the Development of Chronic Pain
title_short	Roles of Long Non-coding RNAs in the Development of Chronic Pain
title_full	Roles of Long Non-coding RNAs in the Development of Chronic Pain
title_fullStr	Roles of Long Non-coding RNAs in the Development of Chronic Pain
title_full_unstemmed	Roles of Long Non-coding RNAs in the Development of Chronic Pain
title_sort	roles of long non-coding rnas in the development of chronic pain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/54984592120047e094de2a499bdf543c
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Roles of Long Non-coding RNAs in the Development of Chronic Pain

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