The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of GOF mutant p53.

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Autores principales:	Catherine A. Vaughan, Shilpa Singh, Mark A. Subler, Jolene J. Windle, Kazushi Inoue, Elizabeth A. Fry, Raghavendra Pillappa, Steven R. Grossman, Brad Windle, W. Andrew Yeudall, Swati Palit Deb, Sumitra Deb
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54a056e3c31c4f638609e87d39e9e921
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spelling	oai:doaj.org-article:54a056e3c31c4f638609e87d39e9e9212021-12-02T13:57:31ZThe oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK310.1038/s41467-021-20928-82041-1723https://doaj.org/article/54a056e3c31c4f638609e87d39e9e9212021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20928-8https://doaj.org/toc/2041-1723The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of GOF mutant p53.Catherine A. VaughanShilpa SinghMark A. SublerJolene J. WindleKazushi InoueElizabeth A. FryRaghavendra PillappaSteven R. GrossmanBrad WindleW. Andrew YeudallSwati Palit DebSumitra DebNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine A. Vaughan Shilpa Singh Mark A. Subler Jolene J. Windle Kazushi Inoue Elizabeth A. Fry Raghavendra Pillappa Steven R. Grossman Brad Windle W. Andrew Yeudall Swati Palit Deb Sumitra Deb The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
description	The mechanisms of how gain-of-function (GOF) mutant p53 drives carcinogenesis are unclear. Here, the authors show that a GOF mutant p53 requires its transactivation capability to induce mouse lung tumors and this is dependent on PLK3 phosphorylation of GOF mutant p53.
format	article
author	Catherine A. Vaughan Shilpa Singh Mark A. Subler Jolene J. Windle Kazushi Inoue Elizabeth A. Fry Raghavendra Pillappa Steven R. Grossman Brad Windle W. Andrew Yeudall Swati Palit Deb Sumitra Deb
author_facet	Catherine A. Vaughan Shilpa Singh Mark A. Subler Jolene J. Windle Kazushi Inoue Elizabeth A. Fry Raghavendra Pillappa Steven R. Grossman Brad Windle W. Andrew Yeudall Swati Palit Deb Sumitra Deb
author_sort	Catherine A. Vaughan
title	The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
title_short	The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
title_full	The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
title_fullStr	The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
title_full_unstemmed	The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
title_sort	oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of plk3
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54a056e3c31c4f638609e87d39e9e921
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The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

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