Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease

Abstract The association of non-motor symptoms (NMSs) with fall-related factors in patients with Parkinson’s disease (PD) remains to be further elucidated in the early stages of the disease. Eighty-six patients with less than 5 years of the onset of PD were retrospectively enrolled in the study. We...

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Autores principales:	Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54a32a5b118a4303a3da8e4a6f962cce
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spelling	oai:doaj.org-article:54a32a5b118a4303a3da8e4a6f962cce2021-12-02T15:54:02ZAssociation of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease10.1038/s41598-021-84720-w2045-2322https://doaj.org/article/54a32a5b118a4303a3da8e4a6f962cce2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84720-whttps://doaj.org/toc/2045-2322Abstract The association of non-motor symptoms (NMSs) with fall-related factors in patients with Parkinson’s disease (PD) remains to be further elucidated in the early stages of the disease. Eighty-six patients with less than 5 years of the onset of PD were retrospectively enrolled in the study. We assessed potential fall-related risk factors including (1) a history of falls during the past year (faller versus non-faller), (2) the fear of falling (FoF), and (3) the freezing of gait (FoG). Different types of NMSs were measured using the Montreal Cognitive Assessment (MoCA), the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Parkinson’s disease Fatigue Scale (PFS), and the Scales for Outcomes in Parkinson’s disease—Autonomic dysfunction (SCOPA-AUT). The faller group (37.2%) showed higher scores for BDI, BAI, PFS, and SCOPA-AUT, compared to the non-faller group. From logistic regression analyses, the prior history of falls was related to the gastrointestinal domain of SCOPA-AUT, FoF was associated with BAI, and gastrointestinal and urinary domains of SCOPA-AUT, and FoG was linked to BAI and gastrointestinal domain of SCOPA-AUT. In conclusion, we found that fall-related risk factors in patients with early PD were highly connected with gastrointestinal dysautonomia.Kyum-Yil KwonSuyeon ParkEun Ji LeeMina LeeHyunjin JuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyum-Yil Kwon Suyeon Park Eun Ji Lee Mina Lee Hyunjin Ju Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
description	Abstract The association of non-motor symptoms (NMSs) with fall-related factors in patients with Parkinson’s disease (PD) remains to be further elucidated in the early stages of the disease. Eighty-six patients with less than 5 years of the onset of PD were retrospectively enrolled in the study. We assessed potential fall-related risk factors including (1) a history of falls during the past year (faller versus non-faller), (2) the fear of falling (FoF), and (3) the freezing of gait (FoG). Different types of NMSs were measured using the Montreal Cognitive Assessment (MoCA), the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Parkinson’s disease Fatigue Scale (PFS), and the Scales for Outcomes in Parkinson’s disease—Autonomic dysfunction (SCOPA-AUT). The faller group (37.2%) showed higher scores for BDI, BAI, PFS, and SCOPA-AUT, compared to the non-faller group. From logistic regression analyses, the prior history of falls was related to the gastrointestinal domain of SCOPA-AUT, FoF was associated with BAI, and gastrointestinal and urinary domains of SCOPA-AUT, and FoG was linked to BAI and gastrointestinal domain of SCOPA-AUT. In conclusion, we found that fall-related risk factors in patients with early PD were highly connected with gastrointestinal dysautonomia.
format	article
author	Kyum-Yil Kwon Suyeon Park Eun Ji Lee Mina Lee Hyunjin Ju
author_facet	Kyum-Yil Kwon Suyeon Park Eun Ji Lee Mina Lee Hyunjin Ju
author_sort	Kyum-Yil Kwon
title	Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
title_short	Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
title_full	Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
title_fullStr	Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
title_full_unstemmed	Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease
title_sort	association of fall risk factors and non-motor symptoms in patients with early parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54a32a5b118a4303a3da8e4a6f962cce
work_keys_str_mv	AT kyumyilkwon associationoffallriskfactorsandnonmotorsymptomsinpatientswithearlyparkinsonsdisease AT suyeonpark associationoffallriskfactorsandnonmotorsymptomsinpatientswithearlyparkinsonsdisease AT eunjilee associationoffallriskfactorsandnonmotorsymptomsinpatientswithearlyparkinsonsdisease AT minalee associationoffallriskfactorsandnonmotorsymptomsinpatientswithearlyparkinsonsdisease AT hyunjinju associationoffallriskfactorsandnonmotorsymptomsinpatientswithearlyparkinsonsdisease
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Association of fall risk factors and non-motor symptoms in patients with early Parkinson’s disease

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