LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat

Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and e...

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Autores principales: Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Ørom, Jörg Heeren, Matthias Blüher, Martin Bilban, Jan-Wilhelm Kornfeld
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d
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spelling oai:doaj.org-article:54a402f6076e4b0fbbecca1070ed468d2021-12-02T14:40:44ZLincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat10.1038/s41467-018-05933-82041-1723https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05933-8https://doaj.org/toc/2041-1723Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.Elena SchmidtInes DhaouadiIsabella GazianoMatteo OliverioPaul KlemmMotoharu AwazawaGerfried MittererEduardo Fernandez-RebolloMarta Pradas-JuniWolfgang WagnerPhilipp HammerschmidtRute LoureiroChristoph KieferNils R. HansmeierSajjad KhaniMatteo BergamiMarkus HeineEvgenia NtiniPeter FrommoltPeter ZentisUlf Andersson ØromJörg HeerenMatthias BlüherMartin BilbanJan-Wilhelm KornfeldNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
description Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure.
format article
author Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
author_facet Elena Schmidt
Ines Dhaouadi
Isabella Gaziano
Matteo Oliverio
Paul Klemm
Motoharu Awazawa
Gerfried Mitterer
Eduardo Fernandez-Rebollo
Marta Pradas-Juni
Wolfgang Wagner
Philipp Hammerschmidt
Rute Loureiro
Christoph Kiefer
Nils R. Hansmeier
Sajjad Khani
Matteo Bergami
Markus Heine
Evgenia Ntini
Peter Frommolt
Peter Zentis
Ulf Andersson Ørom
Jörg Heeren
Matthias Blüher
Martin Bilban
Jan-Wilhelm Kornfeld
author_sort Elena Schmidt
title LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_short LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_full LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_fullStr LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_full_unstemmed LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
title_sort lincrna h19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d
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