TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.

Transient receptor potential (TRP) channels are a family of Ca(2+)-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually c...

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Autores principales:	Young-Cheul Shin, Soo-Yong Shin, Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk So, Dongseop Kwon, Ju-Hong Jeon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54a5eb4c912a481caa370737f176e05c
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id	oai:doaj.org-article:54a5eb4c912a481caa370737f176e05c
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spelling	oai:doaj.org-article:54a5eb4c912a481caa370737f176e05c2021-11-18T08:12:20ZTRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.1932-620310.1371/journal.pone.0047165https://doaj.org/article/54a5eb4c912a481caa370737f176e05c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071747/?tool=EBIhttps://doaj.org/toc/1932-6203Transient receptor potential (TRP) channels are a family of Ca(2+)-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from 'PubMed' and 'PIE the search' (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using 'Cytoscape'. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.Young-Cheul ShinSoo-Yong ShinJung Nyeo ChunHyeon Sung ChoJin Muk LimHong-Gee KimInsuk SoDongseop KwonJu-Hong JeonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47165 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young-Cheul Shin Soo-Yong Shin Jung Nyeo Chun Hyeon Sung Cho Jin Muk Lim Hong-Gee Kim Insuk So Dongseop Kwon Ju-Hong Jeon TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
description	Transient receptor potential (TRP) channels are a family of Ca(2+)-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information accessibility and data utilization. Here, we present the TRIP Database 2.0 (http://www.trpchannel.org) in which many helpful, user-friendly web interfaces have been developed to facilitate knowledge acquisition and inspire new approaches to studying TRP channel functions: 1) the PPI information found in the supplementary data of referred articles was curated; 2) the PPI summary matrix enables users to intuitively grasp overall PPI information; 3) the search capability has been expanded to retrieve information from 'PubMed' and 'PIE the search' (a specialized search engine for PPI-related articles); and 4) the PPI data are available as sif files for network visualization and analysis using 'Cytoscape'. Therefore, our TRIP Database 2.0 is an information hub that works toward advancing data-driven TRP channel research.
format	article
author	Young-Cheul Shin Soo-Yong Shin Jung Nyeo Chun Hyeon Sung Cho Jin Muk Lim Hong-Gee Kim Insuk So Dongseop Kwon Ju-Hong Jeon
author_facet	Young-Cheul Shin Soo-Yong Shin Jung Nyeo Chun Hyeon Sung Cho Jin Muk Lim Hong-Gee Kim Insuk So Dongseop Kwon Ju-Hong Jeon
author_sort	Young-Cheul Shin
title	TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
title_short	TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
title_full	TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
title_fullStr	TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
title_full_unstemmed	TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.
title_sort	trip database 2.0: a manually curated information hub for accessing trp channel interaction network.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/54a5eb4c912a481caa370737f176e05c
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TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network.

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