Emerging role of sertindole in the management of schizophrenia

Stephanie L Cincotta1, Joshua S Rodefer21Georgetown University School of Medicine, Washington DC, USA; 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, USAAbstract: The atypical antipsychotic sertindole is a phenylindole-derived compound that has...

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Autores principales:	Stephanie L Cincotta, Joshua S Rodefer
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/54a61a278221476bac4276dd15dce0b8
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spelling	oai:doaj.org-article:54a61a278221476bac4276dd15dce0b82021-12-02T07:05:45ZEmerging role of sertindole in the management of schizophrenia1176-63281178-2021https://doaj.org/article/54a61a278221476bac4276dd15dce0b82010-07-01T00:00:00Zhttp://www.dovepress.com/emerging-role-of-sertindole-in-the-management-of-schizophrenia-a4803https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Stephanie L Cincotta1, Joshua S Rodefer21Georgetown University School of Medicine, Washington DC, USA; 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, USAAbstract: The atypical antipsychotic sertindole is a phenylindole-derived compound that has affinity for and functions as an antagonist at a number of receptor systems, including dopamine D2 receptors, 5-HT2A and 5-HT2C receptors, and a-1-noradrenergic receptors. Although previous data suggested that sertindole was well tolerated and had good efficacy against both positive and negative symptom clusters, reports of QT prolongation with sertindole prompted its voluntary removal from the market in 1998. After further safety analyses, it recently regained approval and was reintroduced to the European market for the treatment of schizophrenia, where its role in therapy among available atypicals remains unclear. This article evaluates the preclinical and clinical data regarding sertindole&rsquo;s effectiveness and concludes that sertindole continues to demonstrate a number of strengths, including effective management of both positive and negative symptoms, well-tolerated side effects (including little or no sedation, weight gain, and extrapyramidal side effects), and a superior procognitive profile that is unique among atypical antipsychotics. However, minor concerns regarding its sexual side effects and the major consideration of QT prolongation suggest that additional comparative effectiveness studies are needed to determine the superiority of sertindole vs other atypical antipsychotics recently introduced.Keywords: atypical, antipsychotic, cognition, psychosis, 5-HT2, 5-HT6 Stephanie L CincottaJoshua S RodeferDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 429-441 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Stephanie L Cincotta Joshua S Rodefer Emerging role of sertindole in the management of schizophrenia
description	Stephanie L Cincotta1, Joshua S Rodefer21Georgetown University School of Medicine, Washington DC, USA; 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida, USAAbstract: The atypical antipsychotic sertindole is a phenylindole-derived compound that has affinity for and functions as an antagonist at a number of receptor systems, including dopamine D2 receptors, 5-HT2A and 5-HT2C receptors, and a-1-noradrenergic receptors. Although previous data suggested that sertindole was well tolerated and had good efficacy against both positive and negative symptom clusters, reports of QT prolongation with sertindole prompted its voluntary removal from the market in 1998. After further safety analyses, it recently regained approval and was reintroduced to the European market for the treatment of schizophrenia, where its role in therapy among available atypicals remains unclear. This article evaluates the preclinical and clinical data regarding sertindole&rsquo;s effectiveness and concludes that sertindole continues to demonstrate a number of strengths, including effective management of both positive and negative symptoms, well-tolerated side effects (including little or no sedation, weight gain, and extrapyramidal side effects), and a superior procognitive profile that is unique among atypical antipsychotics. However, minor concerns regarding its sexual side effects and the major consideration of QT prolongation suggest that additional comparative effectiveness studies are needed to determine the superiority of sertindole vs other atypical antipsychotics recently introduced.Keywords: atypical, antipsychotic, cognition, psychosis, 5-HT2, 5-HT6
format	article
author	Stephanie L Cincotta Joshua S Rodefer
author_facet	Stephanie L Cincotta Joshua S Rodefer
author_sort	Stephanie L Cincotta
title	Emerging role of sertindole in the management of schizophrenia
title_short	Emerging role of sertindole in the management of schizophrenia
title_full	Emerging role of sertindole in the management of schizophrenia
title_fullStr	Emerging role of sertindole in the management of schizophrenia
title_full_unstemmed	Emerging role of sertindole in the management of schizophrenia
title_sort	emerging role of sertindole in the management of schizophrenia
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/54a61a278221476bac4276dd15dce0b8
work_keys_str_mv	AT stephanielcincotta emergingroleofsertindoleinthemanagementofschizophrenia AT joshuasrodefer emergingroleofsertindoleinthemanagementofschizophrenia
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Emerging role of sertindole in the management of schizophrenia

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