Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

There is growing empirical evidence that certain types of chemotherapy and phototherapy trigger immunogenic cell death and enhance the therapeutic anticancer efficacy of genetic immunotherapy. However, the main challenge is spatiotemporally co-delivering different drugs to maximize the therapeutic i...

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Autores principales:	Chaoqun Ma, Yichao Duan, Chaohui Wu, Erjuan Meng, Pingping Li, Zhenzhong Zhang, Chunhua Zang, Xueling Ren
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Hyaluronic acid PD-L1 Immunogenic cell death Immunotherapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/54a6b67c5e5b4204ae74caeb0ad99bf6
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spelling	oai:doaj.org-article:54a6b67c5e5b4204ae74caeb0ad99bf62021-11-20T04:57:44ZSpatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy1818-087610.1016/j.ajps.2021.07.004https://doaj.org/article/54a6b67c5e5b4204ae74caeb0ad99bf62021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1818087621000593https://doaj.org/toc/1818-0876There is growing empirical evidence that certain types of chemotherapy and phototherapy trigger immunogenic cell death and enhance the therapeutic anticancer efficacy of genetic immunotherapy. However, the main challenge is spatiotemporally co-delivering different drugs to maximize the therapeutic index of the combination therapy. In this study, a drug delivery system (HTCP-Au/shPD-L1/DOX) was designed with a polysaccharide-wrapped shell and a condensed DNA core. To construct the HTCP-Au vector, dodecyl side chains with a polyethylenimine (PEI) head were grafted onto hyaluronic acid, and AuNPs were grafted via Au-S bonds. During drug loading, PEI arrested shRNA plasmid DNA targeting programmed cell death ligand 1 (shPD-L1) via electrostatic interactions. It also formed a PEI-DNA core that was automatically enclosed when aliphatic hydrocarbons pulled the hyaluronic acid backbone. A hydrophobic interlayer consisting of dodecyl bridge chains between the PEI-DNA core and the hyaluronic acid shell was required to accommodate hydrophobic doxorubicin. In vitro and in vivo assays demonstrated that this core-shell drug delivery system could efficiently load and transport three different drugs and effectively target tumors. Moreover, it could activate the immune system, thereby providing promising therapeutic efficacy against tumor growth and metastasis.Chaoqun MaYichao DuanChaohui WuErjuan MengPingping LiZhenzhong ZhangChunhua ZangXueling RenElsevierarticleHyaluronic acidPD-L1Immunogenic cell deathImmunotherapyTherapeutics. PharmacologyRM1-950ENAsian Journal of Pharmaceutical Sciences, Vol 16, Iss 5, Pp 653-664 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hyaluronic acid PD-L1 Immunogenic cell death Immunotherapy Therapeutics. Pharmacology RM1-950
spellingShingle	Hyaluronic acid PD-L1 Immunogenic cell death Immunotherapy Therapeutics. Pharmacology RM1-950 Chaoqun Ma Yichao Duan Chaohui Wu Erjuan Meng Pingping Li Zhenzhong Zhang Chunhua Zang Xueling Ren Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
description	There is growing empirical evidence that certain types of chemotherapy and phototherapy trigger immunogenic cell death and enhance the therapeutic anticancer efficacy of genetic immunotherapy. However, the main challenge is spatiotemporally co-delivering different drugs to maximize the therapeutic index of the combination therapy. In this study, a drug delivery system (HTCP-Au/shPD-L1/DOX) was designed with a polysaccharide-wrapped shell and a condensed DNA core. To construct the HTCP-Au vector, dodecyl side chains with a polyethylenimine (PEI) head were grafted onto hyaluronic acid, and AuNPs were grafted via Au-S bonds. During drug loading, PEI arrested shRNA plasmid DNA targeting programmed cell death ligand 1 (shPD-L1) via electrostatic interactions. It also formed a PEI-DNA core that was automatically enclosed when aliphatic hydrocarbons pulled the hyaluronic acid backbone. A hydrophobic interlayer consisting of dodecyl bridge chains between the PEI-DNA core and the hyaluronic acid shell was required to accommodate hydrophobic doxorubicin. In vitro and in vivo assays demonstrated that this core-shell drug delivery system could efficiently load and transport three different drugs and effectively target tumors. Moreover, it could activate the immune system, thereby providing promising therapeutic efficacy against tumor growth and metastasis.
format	article
author	Chaoqun Ma Yichao Duan Chaohui Wu Erjuan Meng Pingping Li Zhenzhong Zhang Chunhua Zang Xueling Ren
author_facet	Chaoqun Ma Yichao Duan Chaohui Wu Erjuan Meng Pingping Li Zhenzhong Zhang Chunhua Zang Xueling Ren
author_sort	Chaoqun Ma
title	Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
title_short	Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
title_full	Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
title_fullStr	Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
title_full_unstemmed	Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy
title_sort	spatiotemporally co-delivery of triple therapeutic drugs via ha-coating nanosystems for enhanced immunotherapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/54a6b67c5e5b4204ae74caeb0ad99bf6
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Spatiotemporally co-delivery of triple therapeutic drugs via HA-coating nanosystems for enhanced immunotherapy

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