Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis

Faces convey a great amount of socially relevant information related to emotional and mental states, identity and intention. Processing of face information is a key mechanism for social and cognitive development, such that newborn babies are already tuned to recognize and orient to faces and simple...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alice Adiletta, Samantha Pedrana, Orsola Rosa-Salva, Paola Sgadò
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism spectrum disorder face processing social predispositions brain development sodium valproate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/54a93e72c4e841f8bd05da1bc37dbbc5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54a93e72c4e841f8bd05da1bc37dbbc5
record_format	dspace
spelling	oai:doaj.org-article:54a93e72c4e841f8bd05da1bc37dbbc52021-11-11T10:25:16ZSpontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis1662-515310.3389/fnbeh.2021.733140https://doaj.org/article/54a93e72c4e841f8bd05da1bc37dbbc52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.733140/fullhttps://doaj.org/toc/1662-5153Faces convey a great amount of socially relevant information related to emotional and mental states, identity and intention. Processing of face information is a key mechanism for social and cognitive development, such that newborn babies are already tuned to recognize and orient to faces and simple schematic face-like patterns since the first hours of life. Similar to neonates, also non-human primates and domestic chicks have been shown to express orienting responses to faces and schematic face-like patterns. More importantly, existing studies have hypothesized that early disturbances of these mechanisms represent one of the earliest biomarker of social deficits in autism spectrum disorders (ASD). We used VPA exposure to induce neurodevelopmental changes associated with ASD in domestic chicks and tested whether VPA could impact the expression of the animals’ approach responses to schematic face-like stimuli. We found that VPA impairs the chicks’ preference responses to these social stimuli. Based on the results shown here and on previous studies, we propose the domestic chick as animal model to investigate the biological mechanisms underlying face processing deficits in ASD.Alice AdilettaSamantha PedranaOrsola Rosa-SalvaPaola SgadòFrontiers Media S.A.articleautism spectrum disorderface processingsocial predispositionsbrain developmentsodium valproateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder face processing social predispositions brain development sodium valproate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder face processing social predispositions brain development sodium valproate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Alice Adiletta Samantha Pedrana Orsola Rosa-Salva Paola Sgadò Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
description	Faces convey a great amount of socially relevant information related to emotional and mental states, identity and intention. Processing of face information is a key mechanism for social and cognitive development, such that newborn babies are already tuned to recognize and orient to faces and simple schematic face-like patterns since the first hours of life. Similar to neonates, also non-human primates and domestic chicks have been shown to express orienting responses to faces and schematic face-like patterns. More importantly, existing studies have hypothesized that early disturbances of these mechanisms represent one of the earliest biomarker of social deficits in autism spectrum disorders (ASD). We used VPA exposure to induce neurodevelopmental changes associated with ASD in domestic chicks and tested whether VPA could impact the expression of the animals’ approach responses to schematic face-like stimuli. We found that VPA impairs the chicks’ preference responses to these social stimuli. Based on the results shown here and on previous studies, we propose the domestic chick as animal model to investigate the biological mechanisms underlying face processing deficits in ASD.
format	article
author	Alice Adiletta Samantha Pedrana Orsola Rosa-Salva Paola Sgadò
author_facet	Alice Adiletta Samantha Pedrana Orsola Rosa-Salva Paola Sgadò
author_sort	Alice Adiletta
title	Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
title_short	Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
title_full	Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
title_fullStr	Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
title_full_unstemmed	Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis
title_sort	spontaneous visual preference for face-like stimuli is impaired in newly-hatched domestic chicks exposed to valproic acid during embryogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/54a93e72c4e841f8bd05da1bc37dbbc5
work_keys_str_mv	AT aliceadiletta spontaneousvisualpreferenceforfacelikestimuliisimpairedinnewlyhatcheddomesticchicksexposedtovalproicacidduringembryogenesis AT samanthapedrana spontaneousvisualpreferenceforfacelikestimuliisimpairedinnewlyhatcheddomesticchicksexposedtovalproicacidduringembryogenesis AT orsolarosasalva spontaneousvisualpreferenceforfacelikestimuliisimpairedinnewlyhatcheddomesticchicksexposedtovalproicacidduringembryogenesis AT paolasgado spontaneousvisualpreferenceforfacelikestimuliisimpairedinnewlyhatcheddomesticchicksexposedtovalproicacidduringembryogenesis
_version_	1718439125099479040

Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis

Ejemplares similares