Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin

Abolfazl Akbarzadeh1, Nosratollah Zarghami2, Haleh Mikaeili3, Davoud Asgari4, Amir Mohammad Goganian5, Hanie Khaksar Khiabani5, Mohammad Samiei6, Soodabeh Davaran31Department of Medicinal Chemistry, Tabriz University of Medical Sciences, 2Department of Clinical Biochemistry and Laboratory Medicine,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Akbarzadeh A, Zarghami N, Mikaeili H, Asgari D, Goganian AM, Khiabani HK, Samiei M, Davaran S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/54aaec04f7454057a1adb62b5a1c425b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54aaec04f7454057a1adb62b5a1c425b
record_format	dspace
spelling	oai:doaj.org-article:54aaec04f7454057a1adb62b5a1c425b2021-12-02T03:44:12ZSynthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin1177-8903https://doaj.org/article/54aaec04f7454057a1adb62b5a1c425b2012-02-01T00:00:00Zhttp://www.dovepress.com/synthesis-characterization-and-in-vitro-evaluation-of-novel-polymer-co-a9211https://doaj.org/toc/1177-8903Abolfazl Akbarzadeh1, Nosratollah Zarghami2, Haleh Mikaeili3, Davoud Asgari4, Amir Mohammad Goganian5, Hanie Khaksar Khiabani5, Mohammad Samiei6, Soodabeh Davaran31Department of Medicinal Chemistry, Tabriz University of Medical Sciences, 2Department of Clinical Biochemistry and Laboratory Medicine, Division of Medical Biotechnology, Faculty of Medicine, Tabriz University of Medical Sciences, 3Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, 4Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, 5Department of Organic Chemistry, Faculty of Chemistry, University of Tabriz, 6Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranAbstract: Poly (N-isopropylacrylamide-methyl methacrylic acid, PNIPAAm-MAA)-grafted magnetic nanoparticles were synthesized using silane-coated magnetic nanoparticles as a template for radical polymerization of N-isopropylacrylamide and methacrylic acid. Properties of these nanoparticles, such as size, drug-loading efficiency, and drug release kinetics, were evaluated in vitro for targeted and controlled drug delivery. The resulting nanoparticles had a diameter of 100 nm and a doxorubicin-loading efficiency of 75%, significantly higher doxorubicin release at 40&deg;C compared with 37&deg;C, and pH 5.8 compared with pH 7.4, demonstrating their temperature and pH sensitivity, respectively. In addition, the particles were characterized by X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In vitro cytotoxicity testing showed that the PNIPAAm-MAA-coated magnetic nanoparticles had no cytotoxicity and were biocompatible, indicating their potential for biomedical application.Keywords: magnetic nanoparticles, drug loading, doxorubicin release, biocompatibilityAkbarzadeh AZarghami NMikaeili HAsgari DGoganian AMKhiabani HKSamiei MDavaran SDove Medical PressarticleMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol 2012, Iss default, Pp 13-25 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	Medical technology R855-855.5 Chemical technology TP1-1185 Akbarzadeh A Zarghami N Mikaeili H Asgari D Goganian AM Khiabani HK Samiei M Davaran S Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
description	Abolfazl Akbarzadeh1, Nosratollah Zarghami2, Haleh Mikaeili3, Davoud Asgari4, Amir Mohammad Goganian5, Hanie Khaksar Khiabani5, Mohammad Samiei6, Soodabeh Davaran31Department of Medicinal Chemistry, Tabriz University of Medical Sciences, 2Department of Clinical Biochemistry and Laboratory Medicine, Division of Medical Biotechnology, Faculty of Medicine, Tabriz University of Medical Sciences, 3Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, 4Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, 5Department of Organic Chemistry, Faculty of Chemistry, University of Tabriz, 6Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranAbstract: Poly (N-isopropylacrylamide-methyl methacrylic acid, PNIPAAm-MAA)-grafted magnetic nanoparticles were synthesized using silane-coated magnetic nanoparticles as a template for radical polymerization of N-isopropylacrylamide and methacrylic acid. Properties of these nanoparticles, such as size, drug-loading efficiency, and drug release kinetics, were evaluated in vitro for targeted and controlled drug delivery. The resulting nanoparticles had a diameter of 100 nm and a doxorubicin-loading efficiency of 75%, significantly higher doxorubicin release at 40&deg;C compared with 37&deg;C, and pH 5.8 compared with pH 7.4, demonstrating their temperature and pH sensitivity, respectively. In addition, the particles were characterized by X-ray powder diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. In vitro cytotoxicity testing showed that the PNIPAAm-MAA-coated magnetic nanoparticles had no cytotoxicity and were biocompatible, indicating their potential for biomedical application.Keywords: magnetic nanoparticles, drug loading, doxorubicin release, biocompatibility
format	article
author	Akbarzadeh A Zarghami N Mikaeili H Asgari D Goganian AM Khiabani HK Samiei M Davaran S
author_facet	Akbarzadeh A Zarghami N Mikaeili H Asgari D Goganian AM Khiabani HK Samiei M Davaran S
author_sort	Akbarzadeh A
title	Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
title_short	Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
title_full	Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
title_fullStr	Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
title_full_unstemmed	Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
title_sort	synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/54aaec04f7454057a1adb62b5a1c425b
work_keys_str_mv	AT akbarzadeha synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT zarghamin synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT mikaeilih synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT asgarid synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT goganianam synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT khiabanihk synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT samieim synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin AT davarans synthesischaracterizationandinvitroevaluationofnovelpolymercoatedmagneticnanoparticlesforcontrolleddeliveryofdoxorubicin
_version_	1718401630479581184

Synthesis, characterization, and in vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled delivery of doxorubicin

Ejemplares similares