Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.

<h4>Objective</h4>Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as an important pathogen causing healthcare-associated infections (HAIs) in Taiwan. The present study is aimed to investigate the epidemiology of HAIs caused by CRAB and the association of CRAB infection an...

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Autores principales:	Chiu-Hsia Su, Jann-Tay Wang, Chao A Hsiung, Li-Jung Chien, Cheng-Liang Chi, Hui-Tzu Yu, Feng-Yee Chang, Shan-Chwen Chang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54aaf9d9da8446df921ff2dd83fc21c0
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spelling	oai:doaj.org-article:54aaf9d9da8446df921ff2dd83fc21c02021-11-18T07:17:54ZIncrease of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.1932-620310.1371/journal.pone.0037788https://doaj.org/article/54aaf9d9da8446df921ff2dd83fc21c02012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22629456/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as an important pathogen causing healthcare-associated infections (HAIs) in Taiwan. The present study is aimed to investigate the epidemiology of HAIs caused by CRAB and the association of CRAB infection and hospital usage of different antimicrobials.<h4>Methods</h4>Two nationwide databases in the period 2003 to 2008, the Taiwan Nosocomial Infection Surveillance System and National Health Insurance claim data, were used for analysis. A total of 13,811 healthcare-associated A. baumannii infections and antimicrobial usage data from 121 hospitals were analyzed.<h4>Results</h4>There was a significant increase in the proportion of number of HAIs caused by CRAB over that by all A. baumannii (CRABpAB), from 14% in 2003 to 46% in 2008 (P<0.0001). The greatest increase was in central Taiwan, from 4% in 2003 to 62% in 2008 (P<0.0001). Use of anti-pseudomonal carbapenems, but not other classes of antibiotics, was significantly correlated with the increase of CRABpAB (r = 0.86, P<0.0001).<h4>Conclusions</h4>We suggested that dedicated use of anti-pseudomonal carbapenems would be an important intervention to control the increase of CRABpAB.Chiu-Hsia SuJann-Tay WangChao A HsiungLi-Jung ChienCheng-Liang ChiHui-Tzu YuFeng-Yee ChangShan-Chwen ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37788 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chiu-Hsia Su Jann-Tay Wang Chao A Hsiung Li-Jung Chien Cheng-Liang Chi Hui-Tzu Yu Feng-Yee Chang Shan-Chwen Chang Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
description	<h4>Objective</h4>Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as an important pathogen causing healthcare-associated infections (HAIs) in Taiwan. The present study is aimed to investigate the epidemiology of HAIs caused by CRAB and the association of CRAB infection and hospital usage of different antimicrobials.<h4>Methods</h4>Two nationwide databases in the period 2003 to 2008, the Taiwan Nosocomial Infection Surveillance System and National Health Insurance claim data, were used for analysis. A total of 13,811 healthcare-associated A. baumannii infections and antimicrobial usage data from 121 hospitals were analyzed.<h4>Results</h4>There was a significant increase in the proportion of number of HAIs caused by CRAB over that by all A. baumannii (CRABpAB), from 14% in 2003 to 46% in 2008 (P<0.0001). The greatest increase was in central Taiwan, from 4% in 2003 to 62% in 2008 (P<0.0001). Use of anti-pseudomonal carbapenems, but not other classes of antibiotics, was significantly correlated with the increase of CRABpAB (r = 0.86, P<0.0001).<h4>Conclusions</h4>We suggested that dedicated use of anti-pseudomonal carbapenems would be an important intervention to control the increase of CRABpAB.
format	article
author	Chiu-Hsia Su Jann-Tay Wang Chao A Hsiung Li-Jung Chien Cheng-Liang Chi Hui-Tzu Yu Feng-Yee Chang Shan-Chwen Chang
author_facet	Chiu-Hsia Su Jann-Tay Wang Chao A Hsiung Li-Jung Chien Cheng-Liang Chi Hui-Tzu Yu Feng-Yee Chang Shan-Chwen Chang
author_sort	Chiu-Hsia Su
title	Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
title_short	Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
title_full	Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
title_fullStr	Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
title_full_unstemmed	Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.
title_sort	increase of carbapenem-resistant acinetobacter baumannii infection in acute care hospitals in taiwan: association with hospital antimicrobial usage.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/54aaf9d9da8446df921ff2dd83fc21c0
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Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage.

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