ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization

Macrophages employ epigenetic remodeling, especially the regulation of superenhancers (SEs), to promote classical polarization and function; whether liquid-liquid phase separation (LLPS) is involved is not known. Here, the authors show the epigenetic reader ZMYND8 forms condensates to deactivate lat...

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Autores principales:	Pan Jia, Xiang Li, Xuelei Wang, Liangjiao Yao, Yingying Xu, Yu Hu, Wenwen Xu, Zhe He, Qifan Zhao, Yicong Deng, Yi Zang, Meiyu Zhang, Yan Zhang, Jun Qin, Wei Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54acbfc5205748288e148fd06f16199a
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spelling	oai:doaj.org-article:54acbfc5205748288e148fd06f16199a2021-11-14T12:35:52ZZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization10.1038/s41467-021-26864-x2041-1723https://doaj.org/article/54acbfc5205748288e148fd06f16199a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26864-xhttps://doaj.org/toc/2041-1723Macrophages employ epigenetic remodeling, especially the regulation of superenhancers (SEs), to promote classical polarization and function; whether liquid-liquid phase separation (LLPS) is involved is not known. Here, the authors show the epigenetic reader ZMYND8 forms condensates to deactivate latent SEs in a spatiotemporal manner and thereby restrict macrophage-mediated inflammation.Pan JiaXiang LiXuelei WangLiangjiao YaoYingying XuYu HuWenwen XuZhe HeQifan ZhaoYicong DengYi ZangMeiyu ZhangYan ZhangJun QinWei LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pan Jia Xiang Li Xuelei Wang Liangjiao Yao Yingying Xu Yu Hu Wenwen Xu Zhe He Qifan Zhao Yicong Deng Yi Zang Meiyu Zhang Yan Zhang Jun Qin Wei Lu ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
description	Macrophages employ epigenetic remodeling, especially the regulation of superenhancers (SEs), to promote classical polarization and function; whether liquid-liquid phase separation (LLPS) is involved is not known. Here, the authors show the epigenetic reader ZMYND8 forms condensates to deactivate latent SEs in a spatiotemporal manner and thereby restrict macrophage-mediated inflammation.
format	article
author	Pan Jia Xiang Li Xuelei Wang Liangjiao Yao Yingying Xu Yu Hu Wenwen Xu Zhe He Qifan Zhao Yicong Deng Yi Zang Meiyu Zhang Yan Zhang Jun Qin Wei Lu
author_facet	Pan Jia Xiang Li Xuelei Wang Liangjiao Yao Yingying Xu Yu Hu Wenwen Xu Zhe He Qifan Zhao Yicong Deng Yi Zang Meiyu Zhang Yan Zhang Jun Qin Wei Lu
author_sort	Pan Jia
title	ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
title_short	ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
title_full	ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
title_fullStr	ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
title_full_unstemmed	ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
title_sort	zmynd8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54acbfc5205748288e148fd06f16199a
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ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization

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