Runs of homozygosity do not influence survival to old age.
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide poly...
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2011
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oai:doaj.org-article:54b092d209074c3b83c3fd15fa07f3b82021-11-18T06:49:28ZRuns of homozygosity do not influence survival to old age.1932-620310.1371/journal.pone.0022580https://doaj.org/article/54b092d209074c3b83c3fd15fa07f3b82011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799906/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.Maris KuningasRuth McQuillanJames F WilsonAlbert HofmanCornelia M van DuijnAndré G UitterlindenHenning TiemeierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22580 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier Runs of homozygosity do not influence survival to old age. |
| description |
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age. |
| format |
article |
| author |
Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier |
| author_facet |
Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier |
| author_sort |
Maris Kuningas |
| title |
Runs of homozygosity do not influence survival to old age. |
| title_short |
Runs of homozygosity do not influence survival to old age. |
| title_full |
Runs of homozygosity do not influence survival to old age. |
| title_fullStr |
Runs of homozygosity do not influence survival to old age. |
| title_full_unstemmed |
Runs of homozygosity do not influence survival to old age. |
| title_sort |
runs of homozygosity do not influence survival to old age. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/54b092d209074c3b83c3fd15fa07f3b8 |
| work_keys_str_mv |
AT mariskuningas runsofhomozygositydonotinfluencesurvivaltooldage AT ruthmcquillan runsofhomozygositydonotinfluencesurvivaltooldage AT jamesfwilson runsofhomozygositydonotinfluencesurvivaltooldage AT alberthofman runsofhomozygositydonotinfluencesurvivaltooldage AT corneliamvanduijn runsofhomozygositydonotinfluencesurvivaltooldage AT andreguitterlinden runsofhomozygositydonotinfluencesurvivaltooldage AT henningtiemeier runsofhomozygositydonotinfluencesurvivaltooldage |
| _version_ |
1718424351443779584 |