Runs of homozygosity do not influence survival to old age.

Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide poly...

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Autores principales:	Maris Kuningas, Ruth McQuillan, James F Wilson, Albert Hofman, Cornelia M van Duijn, André G Uitterlinden, Henning Tiemeier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54b092d209074c3b83c3fd15fa07f3b8
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id	oai:doaj.org-article:54b092d209074c3b83c3fd15fa07f3b8
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spelling	oai:doaj.org-article:54b092d209074c3b83c3fd15fa07f3b82021-11-18T06:49:28ZRuns of homozygosity do not influence survival to old age.1932-620310.1371/journal.pone.0022580https://doaj.org/article/54b092d209074c3b83c3fd15fa07f3b82011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21799906/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.Maris KuningasRuth McQuillanJames F WilsonAlbert HofmanCornelia M van DuijnAndré G UitterlindenHenning TiemeierPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22580 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier Runs of homozygosity do not influence survival to old age.
description	Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.
format	article
author	Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier
author_facet	Maris Kuningas Ruth McQuillan James F Wilson Albert Hofman Cornelia M van Duijn André G Uitterlinden Henning Tiemeier
author_sort	Maris Kuningas
title	Runs of homozygosity do not influence survival to old age.
title_short	Runs of homozygosity do not influence survival to old age.
title_full	Runs of homozygosity do not influence survival to old age.
title_fullStr	Runs of homozygosity do not influence survival to old age.
title_full_unstemmed	Runs of homozygosity do not influence survival to old age.
title_sort	runs of homozygosity do not influence survival to old age.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/54b092d209074c3b83c3fd15fa07f3b8
work_keys_str_mv	AT mariskuningas runsofhomozygositydonotinfluencesurvivaltooldage AT ruthmcquillan runsofhomozygositydonotinfluencesurvivaltooldage AT jamesfwilson runsofhomozygositydonotinfluencesurvivaltooldage AT alberthofman runsofhomozygositydonotinfluencesurvivaltooldage AT corneliamvanduijn runsofhomozygositydonotinfluencesurvivaltooldage AT andreguitterlinden runsofhomozygositydonotinfluencesurvivaltooldage AT henningtiemeier runsofhomozygositydonotinfluencesurvivaltooldage
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Runs of homozygosity do not influence survival to old age.

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