The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes a helical conformation that leads to receptor...

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Autores principales:	Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54b25db5eb6645b78a4e6e1855d32598
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spelling	oai:doaj.org-article:54b25db5eb6645b78a4e6e1855d325982021-12-02T14:39:53ZThe complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP110.1038/ncomms113442041-1723https://doaj.org/article/54b25db5eb6645b78a4e6e1855d325982016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11344https://doaj.org/toc/2041-1723The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes a helical conformation that leads to receptor activation.Ashish SethiShoni BruellNitin PatilMohammed Akhter HossainDaniel J. ScottEmma J. PetrieRoss A. D. BathgatePaul R. GooleyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashish Sethi Shoni Bruell Nitin Patil Mohammed Akhter Hossain Daniel J. Scott Emma J. Petrie Ross A. D. Bathgate Paul R. Gooley The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
description	The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabilizes a helical conformation that leads to receptor activation.
format	article
author	Ashish Sethi Shoni Bruell Nitin Patil Mohammed Akhter Hossain Daniel J. Scott Emma J. Petrie Ross A. D. Bathgate Paul R. Gooley
author_facet	Ashish Sethi Shoni Bruell Nitin Patil Mohammed Akhter Hossain Daniel J. Scott Emma J. Petrie Ross A. D. Bathgate Paul R. Gooley
author_sort	Ashish Sethi
title	The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
title_short	The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
title_full	The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
title_fullStr	The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
title_full_unstemmed	The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1
title_sort	complex binding mode of the peptide hormone h2 relaxin to its receptor rxfp1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/54b25db5eb6645b78a4e6e1855d32598
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The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

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