MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer

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Autores principales:	Tianzuo Zhan, Giulia Ambrosi, Anna Maxi Wandmacher, Benedikt Rauscher, Johannes Betge, Niklas Rindtorff, Ragna S. Häussler, Isabel Hinsenkamp, Leonhard Bamberg, Bernd Hessling, Karin Müller-Decker, Gerrit Erdmann, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54b4ea38523f4011a819f580a23a3c55
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spelling	oai:doaj.org-article:54b4ea38523f4011a819f580a23a3c552021-12-02T16:58:13ZMEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer10.1038/s41467-019-09898-02041-1723https://doaj.org/article/54b4ea38523f4011a819f580a23a3c552019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09898-0https://doaj.org/toc/2041-1723Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancerTianzuo ZhanGiulia AmbrosiAnna Maxi WandmacherBenedikt RauscherJohannes BetgeNiklas RindtorffRagna S. HäusslerIsabel HinsenkampLeonhard BambergBernd HesslingKarin Müller-DeckerGerrit ErdmannElke BurgermeisterMatthias P. EbertMichael BoutrosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianzuo Zhan Giulia Ambrosi Anna Maxi Wandmacher Benedikt Rauscher Johannes Betge Niklas Rindtorff Ragna S. Häussler Isabel Hinsenkamp Leonhard Bamberg Bernd Hessling Karin Müller-Decker Gerrit Erdmann Elke Burgermeister Matthias P. Ebert Michael Boutros MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
description	Wnt signaling is necessary for colorectal cancer tumorigenesis and stem cell maintenance. Here, the authors identify MEK1/2 inhibitors as potent activators of Wnt/β-catenin signalling and show that clinically approved MEK inhibitors inadvertently induce stem cell plasticity in colorectal cancer
format	article
author	Tianzuo Zhan Giulia Ambrosi Anna Maxi Wandmacher Benedikt Rauscher Johannes Betge Niklas Rindtorff Ragna S. Häussler Isabel Hinsenkamp Leonhard Bamberg Bernd Hessling Karin Müller-Decker Gerrit Erdmann Elke Burgermeister Matthias P. Ebert Michael Boutros
author_facet	Tianzuo Zhan Giulia Ambrosi Anna Maxi Wandmacher Benedikt Rauscher Johannes Betge Niklas Rindtorff Ragna S. Häussler Isabel Hinsenkamp Leonhard Bamberg Bernd Hessling Karin Müller-Decker Gerrit Erdmann Elke Burgermeister Matthias P. Ebert Michael Boutros
author_sort	Tianzuo Zhan
title	MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
title_short	MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
title_full	MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
title_fullStr	MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
title_full_unstemmed	MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
title_sort	mek inhibitors activate wnt signalling and induce stem cell plasticity in colorectal cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/54b4ea38523f4011a819f580a23a3c55
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MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

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