Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Valgerdur Steinthorsdottir, Ralph McGinnis, Nicholas O. Williams, Lilja Stefansdottir, Gudmar Thorleifsson, Scott Shooter, João Fadista, Jon K. Sigurdsson, Kirsi M. Auro, Galina Berezina, Maria-Carolina Borges, Suzannah Bumpstead, Jonas Bybjerg-Grauholm, Irina Colgiu, Vivien A. Dolby, Frank Dudbridge, Stephanie M. Engel, Christopher S. Franklin, Michael L. Frigge, Yr Frisbaek, Reynir T. Geirsson, Frank Geller, Solveig Gretarsdottir, Daniel F. Gudbjartsson, Quaker Harmon, David Michael Hougaard, Tatyana Hegay, Anna Helgadottir, Sigrun Hjartardottir, Tiina Jääskeläinen, Hrefna Johannsdottir, Ingileif Jonsdottir, Thorhildur Juliusdottir, Noor Kalsheker, Abdumadjit Kasimov, John P. Kemp, Katja Kivinen, Kari Klungsøyr, Wai K. Lee, Mads Melbye, Zosia Miedzybrodska, Ashley Moffett, Dilbar Najmutdinova, Firuza Nishanova, Thorunn Olafsdottir, Markus Perola, Fiona Broughton Pipkin, Lucilla Poston, Gordon Prescott, Saedis Saevarsdottir, Damilya Salimbayeva, Paula Juliet Scaife, Line Skotte, Eleonora Staines-Urias, Olafur A. Stefansson, Karina Meden Sørensen, Liv Cecilie Vestrheim Thomsen, Vinicius Tragante, Lill Trogstad, Nigel A. B. Simpson, FINNPEC Consortium, GOPEC Consortium, Tamara Aripova, Juan P. Casas, Anna F. Dominiczak, James J. Walker, Unnur Thorsteinsdottir, Ann-Charlotte Iversen, Bjarke Feenstra, Deborah A. Lawlor, Heather Allison Boyd, Per Magnus, Hannele Laivuori, Nodira Zakhidova, Gulnara Svyatova, Kari Stefansson, Linda Morgan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54b589a97a1246bc8db4f581846322e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54b589a97a1246bc8db4f581846322e3
record_format	dspace
spelling	oai:doaj.org-article:54b589a97a1246bc8db4f581846322e32021-12-02T13:24:05ZGenetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women10.1038/s41467-020-19733-62041-1723https://doaj.org/article/54b589a97a1246bc8db4f581846322e32020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19733-6https://doaj.org/toc/2041-1723Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia.Valgerdur SteinthorsdottirRalph McGinnisNicholas O. WilliamsLilja StefansdottirGudmar ThorleifssonScott ShooterJoão FadistaJon K. SigurdssonKirsi M. AuroGalina BerezinaMaria-Carolina BorgesSuzannah BumpsteadJonas Bybjerg-GrauholmIrina ColgiuVivien A. DolbyFrank DudbridgeStephanie M. EngelChristopher S. FranklinMichael L. FriggeYr FrisbaekReynir T. GeirssonFrank GellerSolveig GretarsdottirDaniel F. GudbjartssonQuaker HarmonDavid Michael HougaardTatyana HegayAnna HelgadottirSigrun HjartardottirTiina JääskeläinenHrefna JohannsdottirIngileif JonsdottirThorhildur JuliusdottirNoor KalshekerAbdumadjit KasimovJohn P. KempKatja KivinenKari KlungsøyrWai K. LeeMads MelbyeZosia MiedzybrodskaAshley MoffettDilbar NajmutdinovaFiruza NishanovaThorunn OlafsdottirMarkus PerolaFiona Broughton PipkinLucilla PostonGordon PrescottSaedis SaevarsdottirDamilya SalimbayevaPaula Juliet ScaifeLine SkotteEleonora Staines-UriasOlafur A. StefanssonKarina Meden SørensenLiv Cecilie Vestrheim ThomsenVinicius TraganteLill TrogstadNigel A. B. SimpsonFINNPEC ConsortiumGOPEC ConsortiumTamara AripovaJuan P. CasasAnna F. DominiczakJames J. WalkerUnnur ThorsteinsdottirAnn-Charlotte IversenBjarke FeenstraDeborah A. LawlorHeather Allison BoydPer MagnusHannele LaivuoriNodira ZakhidovaGulnara SvyatovaKari StefanssonLinda MorganNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valgerdur Steinthorsdottir Ralph McGinnis Nicholas O. Williams Lilja Stefansdottir Gudmar Thorleifsson Scott Shooter João Fadista Jon K. Sigurdsson Kirsi M. Auro Galina Berezina Maria-Carolina Borges Suzannah Bumpstead Jonas Bybjerg-Grauholm Irina Colgiu Vivien A. Dolby Frank Dudbridge Stephanie M. Engel Christopher S. Franklin Michael L. Frigge Yr Frisbaek Reynir T. Geirsson Frank Geller Solveig Gretarsdottir Daniel F. Gudbjartsson Quaker Harmon David Michael Hougaard Tatyana Hegay Anna Helgadottir Sigrun Hjartardottir Tiina Jääskeläinen Hrefna Johannsdottir Ingileif Jonsdottir Thorhildur Juliusdottir Noor Kalsheker Abdumadjit Kasimov John P. Kemp Katja Kivinen Kari Klungsøyr Wai K. Lee Mads Melbye Zosia Miedzybrodska Ashley Moffett Dilbar Najmutdinova Firuza Nishanova Thorunn Olafsdottir Markus Perola Fiona Broughton Pipkin Lucilla Poston Gordon Prescott Saedis Saevarsdottir Damilya Salimbayeva Paula Juliet Scaife Line Skotte Eleonora Staines-Urias Olafur A. Stefansson Karina Meden Sørensen Liv Cecilie Vestrheim Thomsen Vinicius Tragante Lill Trogstad Nigel A. B. Simpson FINNPEC Consortium GOPEC Consortium Tamara Aripova Juan P. Casas Anna F. Dominiczak James J. Walker Unnur Thorsteinsdottir Ann-Charlotte Iversen Bjarke Feenstra Deborah A. Lawlor Heather Allison Boyd Per Magnus Hannele Laivuori Nodira Zakhidova Gulnara Svyatova Kari Stefansson Linda Morgan Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
description	Studies to identify maternal variants associated with preeclampsia have been limited by sample size. Here, the authors meta-analyze eight GWAS of 9,515 preeclamptic women, identifying five variants associated with preeclampsia and showing that genetic predisposition to hypertension is a major risk factor for preeclampsia.
format	article
author	Valgerdur Steinthorsdottir Ralph McGinnis Nicholas O. Williams Lilja Stefansdottir Gudmar Thorleifsson Scott Shooter João Fadista Jon K. Sigurdsson Kirsi M. Auro Galina Berezina Maria-Carolina Borges Suzannah Bumpstead Jonas Bybjerg-Grauholm Irina Colgiu Vivien A. Dolby Frank Dudbridge Stephanie M. Engel Christopher S. Franklin Michael L. Frigge Yr Frisbaek Reynir T. Geirsson Frank Geller Solveig Gretarsdottir Daniel F. Gudbjartsson Quaker Harmon David Michael Hougaard Tatyana Hegay Anna Helgadottir Sigrun Hjartardottir Tiina Jääskeläinen Hrefna Johannsdottir Ingileif Jonsdottir Thorhildur Juliusdottir Noor Kalsheker Abdumadjit Kasimov John P. Kemp Katja Kivinen Kari Klungsøyr Wai K. Lee Mads Melbye Zosia Miedzybrodska Ashley Moffett Dilbar Najmutdinova Firuza Nishanova Thorunn Olafsdottir Markus Perola Fiona Broughton Pipkin Lucilla Poston Gordon Prescott Saedis Saevarsdottir Damilya Salimbayeva Paula Juliet Scaife Line Skotte Eleonora Staines-Urias Olafur A. Stefansson Karina Meden Sørensen Liv Cecilie Vestrheim Thomsen Vinicius Tragante Lill Trogstad Nigel A. B. Simpson FINNPEC Consortium GOPEC Consortium Tamara Aripova Juan P. Casas Anna F. Dominiczak James J. Walker Unnur Thorsteinsdottir Ann-Charlotte Iversen Bjarke Feenstra Deborah A. Lawlor Heather Allison Boyd Per Magnus Hannele Laivuori Nodira Zakhidova Gulnara Svyatova Kari Stefansson Linda Morgan
author_facet	Valgerdur Steinthorsdottir Ralph McGinnis Nicholas O. Williams Lilja Stefansdottir Gudmar Thorleifsson Scott Shooter João Fadista Jon K. Sigurdsson Kirsi M. Auro Galina Berezina Maria-Carolina Borges Suzannah Bumpstead Jonas Bybjerg-Grauholm Irina Colgiu Vivien A. Dolby Frank Dudbridge Stephanie M. Engel Christopher S. Franklin Michael L. Frigge Yr Frisbaek Reynir T. Geirsson Frank Geller Solveig Gretarsdottir Daniel F. Gudbjartsson Quaker Harmon David Michael Hougaard Tatyana Hegay Anna Helgadottir Sigrun Hjartardottir Tiina Jääskeläinen Hrefna Johannsdottir Ingileif Jonsdottir Thorhildur Juliusdottir Noor Kalsheker Abdumadjit Kasimov John P. Kemp Katja Kivinen Kari Klungsøyr Wai K. Lee Mads Melbye Zosia Miedzybrodska Ashley Moffett Dilbar Najmutdinova Firuza Nishanova Thorunn Olafsdottir Markus Perola Fiona Broughton Pipkin Lucilla Poston Gordon Prescott Saedis Saevarsdottir Damilya Salimbayeva Paula Juliet Scaife Line Skotte Eleonora Staines-Urias Olafur A. Stefansson Karina Meden Sørensen Liv Cecilie Vestrheim Thomsen Vinicius Tragante Lill Trogstad Nigel A. B. Simpson FINNPEC Consortium GOPEC Consortium Tamara Aripova Juan P. Casas Anna F. Dominiczak James J. Walker Unnur Thorsteinsdottir Ann-Charlotte Iversen Bjarke Feenstra Deborah A. Lawlor Heather Allison Boyd Per Magnus Hannele Laivuori Nodira Zakhidova Gulnara Svyatova Kari Stefansson Linda Morgan
author_sort	Valgerdur Steinthorsdottir
title	Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
title_short	Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
title_full	Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
title_fullStr	Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
title_full_unstemmed	Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
title_sort	genetic predisposition to hypertension is associated with preeclampsia in european and central asian women
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/54b589a97a1246bc8db4f581846322e3
work_keys_str_mv	AT valgerdursteinthorsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT ralphmcginnis geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT nicholasowilliams geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT liljastefansdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT gudmarthorleifsson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT scottshooter geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT joaofadista geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT jonksigurdsson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT kirsimauro geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT galinaberezina geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT mariacarolinaborges geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT suzannahbumpstead geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT jonasbybjerggrauholm geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT irinacolgiu geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT vivienadolby geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT frankdudbridge geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT stephaniemengel geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT christophersfranklin geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT michaellfrigge geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT yrfrisbaek geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT reynirtgeirsson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT frankgeller geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT solveiggretarsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT danielfgudbjartsson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT quakerharmon geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT davidmichaelhougaard geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT tatyanahegay geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT annahelgadottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT sigrunhjartardottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT tiinajaaskelainen geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT hrefnajohannsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT ingileifjonsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT thorhildurjuliusdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT noorkalsheker geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT abdumadjitkasimov geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT johnpkemp geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT katjakivinen geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT kariklungsøyr geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT waiklee geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT madsmelbye geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT zosiamiedzybrodska geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT ashleymoffett geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT dilbarnajmutdinova geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT firuzanishanova geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT thorunnolafsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT markusperola geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT fionabroughtonpipkin geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT lucillaposton geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT gordonprescott geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT saedissaevarsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT damilyasalimbayeva geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT paulajulietscaife geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT lineskotte geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT eleonorastainesurias geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT olafurastefansson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT karinamedensørensen geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT livcecilievestrheimthomsen geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT viniciustragante geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT lilltrogstad geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT nigelabsimpson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT finnpecconsortium geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT gopecconsortium geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT tamaraaripova geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT juanpcasas geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT annafdominiczak geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT jamesjwalker geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT unnurthorsteinsdottir geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT anncharlotteiversen geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT bjarkefeenstra geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT deborahalawlor geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT heatherallisonboyd geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT permagnus geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT hannelelaivuori geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT nodirazakhidova geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT gulnarasvyatova geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT karistefansson geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen AT lindamorgan geneticpredispositiontohypertensionisassociatedwithpreeclampsiaineuropeanandcentralasianwomen
_version_	1718393149450092544

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Ejemplares similares