Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight

Hayashi et al. report on the effect of space flight on muscle mass, fibre size and type, composition and gene signalling of muscle in WT and Nrf2-KO mice. Their results demonstrate a key role of NRF2 in maintaining the slow-type fibres of soleus muscle during space flight and in microgravity environ...

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Autores principales:	Takuto Hayashi, Takashi Kudo, Ryo Fujita, Shin-ichiro Fujita, Hirona Tsubouchi, Sayaka Fuseya, Riku Suzuki, Michito Hamada, Risa Okada, Masafumi Muratani, Dai Shiba, Takafumi Suzuki, Eiji Warabi, Masayuki Yamamoto, Satoru Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/54b77403fca14ea68b052687eebe637e
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spelling	oai:doaj.org-article:54b77403fca14ea68b052687eebe637e2021-12-02T17:44:54ZNuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight10.1038/s42003-021-02334-42399-3642https://doaj.org/article/54b77403fca14ea68b052687eebe637e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02334-4https://doaj.org/toc/2399-3642Hayashi et al. report on the effect of space flight on muscle mass, fibre size and type, composition and gene signalling of muscle in WT and Nrf2-KO mice. Their results demonstrate a key role of NRF2 in maintaining the slow-type fibres of soleus muscle during space flight and in microgravity environments.Takuto HayashiTakashi KudoRyo FujitaShin-ichiro FujitaHirona TsubouchiSayaka FuseyaRiku SuzukiMichito HamadaRisa OkadaMasafumi MurataniDai ShibaTakafumi SuzukiEiji WarabiMasayuki YamamotoSatoru TakahashiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Takuto Hayashi Takashi Kudo Ryo Fujita Shin-ichiro Fujita Hirona Tsubouchi Sayaka Fuseya Riku Suzuki Michito Hamada Risa Okada Masafumi Muratani Dai Shiba Takafumi Suzuki Eiji Warabi Masayuki Yamamoto Satoru Takahashi Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
description	Hayashi et al. report on the effect of space flight on muscle mass, fibre size and type, composition and gene signalling of muscle in WT and Nrf2-KO mice. Their results demonstrate a key role of NRF2 in maintaining the slow-type fibres of soleus muscle during space flight and in microgravity environments.
format	article
author	Takuto Hayashi Takashi Kudo Ryo Fujita Shin-ichiro Fujita Hirona Tsubouchi Sayaka Fuseya Riku Suzuki Michito Hamada Risa Okada Masafumi Muratani Dai Shiba Takafumi Suzuki Eiji Warabi Masayuki Yamamoto Satoru Takahashi
author_facet	Takuto Hayashi Takashi Kudo Ryo Fujita Shin-ichiro Fujita Hirona Tsubouchi Sayaka Fuseya Riku Suzuki Michito Hamada Risa Okada Masafumi Muratani Dai Shiba Takafumi Suzuki Eiji Warabi Masayuki Yamamoto Satoru Takahashi
author_sort	Takuto Hayashi
title	Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
title_short	Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
title_full	Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
title_fullStr	Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
title_full_unstemmed	Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
title_sort	nuclear factor e2-related factor 2 (nrf2) deficiency accelerates fast fibre type transition in soleus muscle during space flight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54b77403fca14ea68b052687eebe637e
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Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight

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