A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity.
<h4>Background</h4>Approximately 200 million people worldwide harbour parasitic flatworm infections that cause schistosomiasis. A single drug-praziquantel (PZQ)-has served as the mainstay pharmacotherapy for schistosome infections since the 1980s. However, the relevant in vivo target(s)...
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Main Authors: | Taisaku Nogi, Dan Zhang, John D Chan, Jonathan S Marchant |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2009
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Online Access: | https://doaj.org/article/54ba41af79114d84ae2c8babca92ef9a |
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