GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS

Abstract Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease. CD68-positive bone marrow (BM)-derived cells (BMDCs) accumulate in the pathological lesion in the SOD1(G93A) ALS mouse model after BM transplantation (BMT). Therefore, we investigated whether BMDCs can be appli...

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Bibliographic Details
Main Authors: Natsuko Ohashi, Tomoya Terashima, Miwako Katagi, Yuki Nakae, Junko Okano, Yoshihisa Suzuki, Hideto Kojima
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/54be9e626a714971ae9b84bc8055e8a3
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