Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota

Abstract Glyphosate-based herbicides (GBHs) can disrupt the host microbiota and influence human health. In this study, we explored the potential effects of GBHs on urinary metabolites and their interactions with gut microbiome using a rodent model. Glyphosate and Roundup (equal molar for glyphosate)...

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Autores principales:	Jianzhong Hu, Corina Lesseur, Yu Miao, Fabiana Manservisi, Simona Panzacchi, Daniele Mandrioli, Fiorella Belpoggi, Jia Chen, Lauren Petrick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54bf38fbce044dc9a3ffa5f627133c65
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spelling	oai:doaj.org-article:54bf38fbce044dc9a3ffa5f627133c652021-12-02T14:06:49ZLow-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota10.1038/s41598-021-82552-22045-2322https://doaj.org/article/54bf38fbce044dc9a3ffa5f627133c652021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82552-2https://doaj.org/toc/2045-2322Abstract Glyphosate-based herbicides (GBHs) can disrupt the host microbiota and influence human health. In this study, we explored the potential effects of GBHs on urinary metabolites and their interactions with gut microbiome using a rodent model. Glyphosate and Roundup (equal molar for glyphosate) were administered at the USA glyphosate ADI guideline (1.75 mg/kg bw/day) to the dams and their pups. The urine metabolites were profiled using non-targeted liquid chromatography—high resolution mass spectrometry (LC-HRMS). Our results found that overall urine metabolite profiles significantly differed between dams and pups and between female and male pups. Specifically, we identified a significant increase of homocysteine, a known risk factor of cardiovascular disease in both Roundup and glyphosate exposed pups, but in males only. Correlation network analysis between gut microbiome and urine metabolome pointed to Prevotella to be negatively correlated with the level of homocysteine. Our study provides initial evidence that exposures to commonly used GBH, at a currently acceptable human exposure dose, is capable of modifying urine metabolites in both rat adults and pups. The link between Prevotella-homocysteine suggests the potential role of GBHs in modifying the susceptibility of homocysteine, which is a metabolite that has been dysregulated in related diseases like cardiovascular disease or inflammation, through commensal microbiome.Jianzhong HuCorina LesseurYu MiaoFabiana ManservisiSimona PanzacchiDaniele MandrioliFiorella BelpoggiJia ChenLauren PetrickNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianzhong Hu Corina Lesseur Yu Miao Fabiana Manservisi Simona Panzacchi Daniele Mandrioli Fiorella Belpoggi Jia Chen Lauren Petrick Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
description	Abstract Glyphosate-based herbicides (GBHs) can disrupt the host microbiota and influence human health. In this study, we explored the potential effects of GBHs on urinary metabolites and their interactions with gut microbiome using a rodent model. Glyphosate and Roundup (equal molar for glyphosate) were administered at the USA glyphosate ADI guideline (1.75 mg/kg bw/day) to the dams and their pups. The urine metabolites were profiled using non-targeted liquid chromatography—high resolution mass spectrometry (LC-HRMS). Our results found that overall urine metabolite profiles significantly differed between dams and pups and between female and male pups. Specifically, we identified a significant increase of homocysteine, a known risk factor of cardiovascular disease in both Roundup and glyphosate exposed pups, but in males only. Correlation network analysis between gut microbiome and urine metabolome pointed to Prevotella to be negatively correlated with the level of homocysteine. Our study provides initial evidence that exposures to commonly used GBH, at a currently acceptable human exposure dose, is capable of modifying urine metabolites in both rat adults and pups. The link between Prevotella-homocysteine suggests the potential role of GBHs in modifying the susceptibility of homocysteine, which is a metabolite that has been dysregulated in related diseases like cardiovascular disease or inflammation, through commensal microbiome.
format	article
author	Jianzhong Hu Corina Lesseur Yu Miao Fabiana Manservisi Simona Panzacchi Daniele Mandrioli Fiorella Belpoggi Jia Chen Lauren Petrick
author_facet	Jianzhong Hu Corina Lesseur Yu Miao Fabiana Manservisi Simona Panzacchi Daniele Mandrioli Fiorella Belpoggi Jia Chen Lauren Petrick
author_sort	Jianzhong Hu
title	Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
title_short	Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
title_full	Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
title_fullStr	Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
title_full_unstemmed	Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
title_sort	low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54bf38fbce044dc9a3ffa5f627133c65
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Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota

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