Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring
Abstract Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains to be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used to investigate whether excessive intrauterine lipid...
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Nature Portfolio
2021
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oai:doaj.org-article:54c35a784718443fa28c81aeb3762e042021-12-02T15:23:06ZMaternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring10.1038/s41598-020-79604-42045-2322https://doaj.org/article/54c35a784718443fa28c81aeb3762e042021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79604-4https://doaj.org/toc/2045-2322Abstract Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains to be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used to investigate whether excessive intrauterine lipid exposure was associated with elevated blood pressure in offspring and increased levels of leptin, an important biomarker and mediator of vascular dysfunction and hypertension. We found that gestational hyperlipidemia predisposed offspring to blood pressure elevation and sustained increases in leptin levels with no difference in body weight in the rat model. Increased leptin expression and leptin promoter hypomethylation were found in adipose tissues of HFD-exposed offspring. The treatment of mesenchymal stem cells with free fatty acids during adipogenic differentiation resulted in increased leptin expression, accompanied by leptin promoter hypomethylation. In addition, we also followed up 121 children to evaluate the association between maternal triglyceride levels and offspring blood pressure. Consistent with the animal study results, we observed elevated serum leptin levels and blood pressure in the offspring born to women with gestational hypertriglyceridemia. Our findings provide new insights that maternal hyperlipidemia is associated with elevated blood pressure in offspring and is associated with increases in leptin levels through epigenetic memory.Xian-Hua LinLing GaoShen TianChristian KlausenMeng-Xi GuoQian GaoMiao-E. LiuHui WangDan-Dan WuCheng-Liang ZhouJing YangYe MengYe LiuGu-Feng XuYa-Jing TanKamran UllahYi-Min ZhuWilliam D. FraserJian-Zhong ShengPeter C. K. LeungLouis J. MugliaYan-Ting WuHe-Feng HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
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Medicine R Science Q Xian-Hua Lin Ling Gao Shen Tian Christian Klausen Meng-Xi Guo Qian Gao Miao-E. Liu Hui Wang Dan-Dan Wu Cheng-Liang Zhou Jing Yang Ye Meng Ye Liu Gu-Feng Xu Ya-Jing Tan Kamran Ullah Yi-Min Zhu William D. Fraser Jian-Zhong Sheng Peter C. K. Leung Louis J. Muglia Yan-Ting Wu He-Feng Huang Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| description |
Abstract Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains to be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used to investigate whether excessive intrauterine lipid exposure was associated with elevated blood pressure in offspring and increased levels of leptin, an important biomarker and mediator of vascular dysfunction and hypertension. We found that gestational hyperlipidemia predisposed offspring to blood pressure elevation and sustained increases in leptin levels with no difference in body weight in the rat model. Increased leptin expression and leptin promoter hypomethylation were found in adipose tissues of HFD-exposed offspring. The treatment of mesenchymal stem cells with free fatty acids during adipogenic differentiation resulted in increased leptin expression, accompanied by leptin promoter hypomethylation. In addition, we also followed up 121 children to evaluate the association between maternal triglyceride levels and offspring blood pressure. Consistent with the animal study results, we observed elevated serum leptin levels and blood pressure in the offspring born to women with gestational hypertriglyceridemia. Our findings provide new insights that maternal hyperlipidemia is associated with elevated blood pressure in offspring and is associated with increases in leptin levels through epigenetic memory. |
| format |
article |
| author |
Xian-Hua Lin Ling Gao Shen Tian Christian Klausen Meng-Xi Guo Qian Gao Miao-E. Liu Hui Wang Dan-Dan Wu Cheng-Liang Zhou Jing Yang Ye Meng Ye Liu Gu-Feng Xu Ya-Jing Tan Kamran Ullah Yi-Min Zhu William D. Fraser Jian-Zhong Sheng Peter C. K. Leung Louis J. Muglia Yan-Ting Wu He-Feng Huang |
| author_facet |
Xian-Hua Lin Ling Gao Shen Tian Christian Klausen Meng-Xi Guo Qian Gao Miao-E. Liu Hui Wang Dan-Dan Wu Cheng-Liang Zhou Jing Yang Ye Meng Ye Liu Gu-Feng Xu Ya-Jing Tan Kamran Ullah Yi-Min Zhu William D. Fraser Jian-Zhong Sheng Peter C. K. Leung Louis J. Muglia Yan-Ting Wu He-Feng Huang |
| author_sort |
Xian-Hua Lin |
| title |
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| title_short |
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| title_full |
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| title_fullStr |
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| title_full_unstemmed |
Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| title_sort |
maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/54c35a784718443fa28c81aeb3762e04 |
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