Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring

Maternal high-fat-diet exposure is associated with elevated blood pressure and sustained increased leptin levels through epigenetic memory in offspring

Abstract Maternal metabolism dysregulation during pregnancy predisposes offspring to major diseases, including hypertension, in later life, but the mechanism involved remains to be fully elucidated. A high-fat-diet (HFD) pregnant rat model was used to investigate whether excessive intrauterine lipid...

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Bibliographic Details
Main Authors: Xian-Hua Lin, Ling Gao, Shen Tian, Christian Klausen, Meng-Xi Guo, Qian Gao, Miao-E. Liu, Hui Wang, Dan-Dan Wu, Cheng-Liang Zhou, Jing Yang, Ye Meng, Ye Liu, Gu-Feng Xu, Ya-Jing Tan, Kamran Ullah, Yi-Min Zhu, William D. Fraser, Jian-Zhong Sheng, Peter C. K. Leung, Louis J. Muglia, Yan-Ting Wu, He-Feng Huang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/54c35a784718443fa28c81aeb3762e04
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