CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study

Giant cell tumor of bone (GCTB) is a primary bone neoplasm which is characterized by the presence of mononuclear cells (MCs) and osteoclast-like multinucleated giant cells (MNGCs). Up to our knowledge, CD10 immunoreactivity in GCTB has not yet been studied, and only one study touched on CD138 immuno...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mousa A Al-Abbadi, Mohammed J Al-Yousef, Mohammad M Yousef, Salwa S Sheikh, Nidal M Almasri, Samir S Amr
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2016
Materias:	cd10 cd138 giant cell tumor of bone Medicine R
Acceso en línea:	https://doaj.org/article/54c978d1e9844c5186edeedf10d7c183
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54c978d1e9844c5186edeedf10d7c183
record_format	dspace
spelling	oai:doaj.org-article:54c978d1e9844c5186edeedf10d7c1832021-12-02T17:58:43ZCD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study2231-07702249-446410.4103/2231-0770.184063https://doaj.org/article/54c978d1e9844c5186edeedf10d7c1832016-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.184063https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464Giant cell tumor of bone (GCTB) is a primary bone neoplasm which is characterized by the presence of mononuclear cells (MCs) and osteoclast-like multinucleated giant cells (MNGCs). Up to our knowledge, CD10 immunoreactivity in GCTB has not yet been studied, and only one study touched on CD138 immunoreactivity in GCTB. The objective of this study is to investigate the immunoreactivity of CD10 and CD138 in GCTB. We offer a discussion of our findings in the context of the differential diagnosis, particularly in small biopsy material. We retrieved and reviewed 15 well-documented cases of GCTB from January 2008 to December 2014. Well-controlled standard immunohistochemical satins were performed on these cases for CD10 and CD138 and few other selected antibodies. Immunoreactivity for CD10 was membranous and was found in 14 (93%) cases. This immunoreactivity was found only in the MCs, whereas the MNGC were all negative. CD138 showed variable positivity in 11 (73%) while 4 (37%) were completely negative. Similar to CD10, staining for CD138 was only seen in the MC; however, the immunoreactivity was predominantly concentrated in the peri-vascular areas. Most of GCTB cases can show variable immunoreactivity for CD10 and CD138. The aforementioned immune-expression raise the possibility of a role in the pathogenesis of GCTB. Paying attention to this immunoreactivity is recommended when considering the clinical and radiological differential diagnosis, especially in small biopsy specimens.Mousa A Al-AbbadiMohammed J Al-YousefMohammad M YousefSalwa S SheikhNidal M AlmasriSamir S AmrThieme Medical and Scientific Publishers Pvt. Ltd.articlecd10cd138giant cell tumor of boneMedicineRENAvicenna Journal of Medicine, Vol 06, Iss 03, Pp 69-74 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	cd10 cd138 giant cell tumor of bone Medicine R
spellingShingle	cd10 cd138 giant cell tumor of bone Medicine R Mousa A Al-Abbadi Mohammed J Al-Yousef Mohammad M Yousef Salwa S Sheikh Nidal M Almasri Samir S Amr CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
description	Giant cell tumor of bone (GCTB) is a primary bone neoplasm which is characterized by the presence of mononuclear cells (MCs) and osteoclast-like multinucleated giant cells (MNGCs). Up to our knowledge, CD10 immunoreactivity in GCTB has not yet been studied, and only one study touched on CD138 immunoreactivity in GCTB. The objective of this study is to investigate the immunoreactivity of CD10 and CD138 in GCTB. We offer a discussion of our findings in the context of the differential diagnosis, particularly in small biopsy material. We retrieved and reviewed 15 well-documented cases of GCTB from January 2008 to December 2014. Well-controlled standard immunohistochemical satins were performed on these cases for CD10 and CD138 and few other selected antibodies. Immunoreactivity for CD10 was membranous and was found in 14 (93%) cases. This immunoreactivity was found only in the MCs, whereas the MNGC were all negative. CD138 showed variable positivity in 11 (73%) while 4 (37%) were completely negative. Similar to CD10, staining for CD138 was only seen in the MC; however, the immunoreactivity was predominantly concentrated in the peri-vascular areas. Most of GCTB cases can show variable immunoreactivity for CD10 and CD138. The aforementioned immune-expression raise the possibility of a role in the pathogenesis of GCTB. Paying attention to this immunoreactivity is recommended when considering the clinical and radiological differential diagnosis, especially in small biopsy specimens.
format	article
author	Mousa A Al-Abbadi Mohammed J Al-Yousef Mohammad M Yousef Salwa S Sheikh Nidal M Almasri Samir S Amr
author_facet	Mousa A Al-Abbadi Mohammed J Al-Yousef Mohammad M Yousef Salwa S Sheikh Nidal M Almasri Samir S Amr
author_sort	Mousa A Al-Abbadi
title	CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
title_short	CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
title_full	CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
title_fullStr	CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
title_full_unstemmed	CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study
title_sort	cd10 and cd138 can be expressed in giant cell tumor of bone: an immunohistochemical study
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2016
url	https://doaj.org/article/54c978d1e9844c5186edeedf10d7c183
work_keys_str_mv	AT mousaaalabbadi cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy AT mohammedjalyousef cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy AT mohammadmyousef cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy AT salwassheikh cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy AT nidalmalmasri cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy AT samirsamr cd10andcd138canbeexpressedingiantcelltumorofboneanimmunohistochemicalstudy
_version_	1718378988628344832

CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study

Ejemplares similares