A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility

Abstract Dental implants are an increasingly popular way to replace missing teeth. Whilst implant survival rates are high, a small number fail soon after placement, with various factors, including bacterial contamination, capable of disrupting osseointegration. This work describes the development of...

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Autores principales:	Sarah J. Garner, Mathew J. Dalby, Angela H. Nobbs, Michele E. Barbour
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/54ce7bb98ceb4047ad4a5a75adbabba6
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spelling	oai:doaj.org-article:54ce7bb98ceb4047ad4a5a75adbabba62021-11-21T12:29:47ZA novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility10.1007/s10856-021-06616-50957-45301573-4838https://doaj.org/article/54ce7bb98ceb4047ad4a5a75adbabba62021-11-01T00:00:00Zhttps://doi.org/10.1007/s10856-021-06616-5https://doaj.org/toc/0957-4530https://doaj.org/toc/1573-4838Abstract Dental implants are an increasingly popular way to replace missing teeth. Whilst implant survival rates are high, a small number fail soon after placement, with various factors, including bacterial contamination, capable of disrupting osseointegration. This work describes the development of chlorhexidine-hexametaphosphate coatings for titanium that hydrolyse to release the antiseptic agent chlorhexidine. The aim was to develop a coating for titanium that released sufficient chlorhexidine to prevent biofilm formation, whilst simultaneously maintaining cytocompatibility with cells involved in osseointegration. The coatings were characterised with respect to physical properties, after which antibiofilm efficacy was investigated using a multispecies biofilm model, and cytocompatibility determined using human mesenchymal stem cells. The coatings exhibited similar physicochemical properties to some implant surfaces in clinical use, and significantly reduced formation of multispecies biofilm biomass up to 72 h. One coating had superior cytocompatibility, with mesenchymal stem cells able to perform normal functions and commence osteoblastic differentiation, although at a slower rate than those grown on uncoated titanium. With further refinement, these coatings may have application in the prevention of bacterial contamination of dental implants at the time of surgery. This could aid a reduction in rates of early implant failure.Sarah J. GarnerMathew J. DalbyAngela H. NobbsMichele E. BarbourSpringerarticleMaterials of engineering and construction. Mechanics of materialsTA401-492Medical technologyR855-855.5ENJournal of Materials Science: Materials in Medicine, Vol 32, Iss 12, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5
spellingShingle	Materials of engineering and construction. Mechanics of materials TA401-492 Medical technology R855-855.5 Sarah J. Garner Mathew J. Dalby Angela H. Nobbs Michele E. Barbour A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
description	Abstract Dental implants are an increasingly popular way to replace missing teeth. Whilst implant survival rates are high, a small number fail soon after placement, with various factors, including bacterial contamination, capable of disrupting osseointegration. This work describes the development of chlorhexidine-hexametaphosphate coatings for titanium that hydrolyse to release the antiseptic agent chlorhexidine. The aim was to develop a coating for titanium that released sufficient chlorhexidine to prevent biofilm formation, whilst simultaneously maintaining cytocompatibility with cells involved in osseointegration. The coatings were characterised with respect to physical properties, after which antibiofilm efficacy was investigated using a multispecies biofilm model, and cytocompatibility determined using human mesenchymal stem cells. The coatings exhibited similar physicochemical properties to some implant surfaces in clinical use, and significantly reduced formation of multispecies biofilm biomass up to 72 h. One coating had superior cytocompatibility, with mesenchymal stem cells able to perform normal functions and commence osteoblastic differentiation, although at a slower rate than those grown on uncoated titanium. With further refinement, these coatings may have application in the prevention of bacterial contamination of dental implants at the time of surgery. This could aid a reduction in rates of early implant failure.
format	article
author	Sarah J. Garner Mathew J. Dalby Angela H. Nobbs Michele E. Barbour
author_facet	Sarah J. Garner Mathew J. Dalby Angela H. Nobbs Michele E. Barbour
author_sort	Sarah J. Garner
title	A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
title_short	A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
title_full	A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
title_fullStr	A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
title_full_unstemmed	A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
title_sort	novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility
publisher	Springer
publishDate	2021
url	https://doaj.org/article/54ce7bb98ceb4047ad4a5a75adbabba6
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A novel chlorhexidine-hexametaphosphate coating for titanium with antibiofilm efficacy and stem cell cytocompatibility

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