miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.

Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and ep...

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Autores principales:	Yuanming Shen, Jiansong Zhou, Yang Li, Feng Ye, Xiaoyun Wan, Weiguo Lu, Xing Xie, Xiaodong Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54d10d36836e44f2b423201bfd009fc6
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spelling	oai:doaj.org-article:54d10d36836e44f2b423201bfd009fc62021-11-25T05:56:17ZmiR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.1932-620310.1371/journal.pone.0109299https://doaj.org/article/54d10d36836e44f2b423201bfd009fc62014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109299https://doaj.org/toc/1932-6203Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and epithelial-mesenchymal transition inducement in cervical cancer. Using different cervical cancer cell models, we found that paclitaxel transiently induced up-regulation of miR-375 expression, proliferation inhibition, transition from epithelial to mesenchymal phenotype, and consequently impaired paclitaxel sensitivity. Forced over-expression of miR-375 may suppress Ecadherin expression by a directly targeting pathway, which led to paclitaxel resistance. Contrarily, re-expression of Ecadherin partly reversed epithelial-mesenchymal transition phenotype and miR-375 induced paclitaxel-resistance. Our findings suggest that paclitaxel-induced miR-375 over-expression facilitates epithelial-mesenchymal transition process via directly targeting Ecadherin, proliferation inhibition, and consequently results in chemo-resistance in cervical cancer cells. A reversion of miR-375 or Ecadherin expression may be a novel therapeutic approach for overcoming chemo-resistance in cervical cancer.Yuanming ShenJiansong ZhouYang LiFeng YeXiaoyun WanWeiguo LuXing XieXiaodong ChengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109299 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuanming Shen Jiansong Zhou Yang Li Feng Ye Xiaoyun Wan Weiguo Lu Xing Xie Xiaodong Cheng miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
description	Acquired chemo-resistance is one of the key causal factors in cancer death. Emerging evidences suggest that miRNA and epithelial-mesenchymal transition play critical roles in the chemo-resistance in cancers. Here, we showed the association of paclitaxel-resistance with miR-375 over-expression and epithelial-mesenchymal transition inducement in cervical cancer. Using different cervical cancer cell models, we found that paclitaxel transiently induced up-regulation of miR-375 expression, proliferation inhibition, transition from epithelial to mesenchymal phenotype, and consequently impaired paclitaxel sensitivity. Forced over-expression of miR-375 may suppress Ecadherin expression by a directly targeting pathway, which led to paclitaxel resistance. Contrarily, re-expression of Ecadherin partly reversed epithelial-mesenchymal transition phenotype and miR-375 induced paclitaxel-resistance. Our findings suggest that paclitaxel-induced miR-375 over-expression facilitates epithelial-mesenchymal transition process via directly targeting Ecadherin, proliferation inhibition, and consequently results in chemo-resistance in cervical cancer cells. A reversion of miR-375 or Ecadherin expression may be a novel therapeutic approach for overcoming chemo-resistance in cervical cancer.
format	article
author	Yuanming Shen Jiansong Zhou Yang Li Feng Ye Xiaoyun Wan Weiguo Lu Xing Xie Xiaodong Cheng
author_facet	Yuanming Shen Jiansong Zhou Yang Li Feng Ye Xiaoyun Wan Weiguo Lu Xing Xie Xiaodong Cheng
author_sort	Yuanming Shen
title	miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
title_short	miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
title_full	miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
title_fullStr	miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
title_full_unstemmed	miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.
title_sort	mir-375 mediated acquired chemo-resistance in cervical cancer by facilitating emt.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/54d10d36836e44f2b423201bfd009fc6
work_keys_str_mv	AT yuanmingshen mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT jiansongzhou mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT yangli mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT fengye mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT xiaoyunwan mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT weiguolu mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT xingxie mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt AT xiaodongcheng mir375mediatedacquiredchemoresistanceincervicalcancerbyfacilitatingemt
_version_	1718414337788346368

miR-375 mediated acquired chemo-resistance in cervical cancer by facilitating EMT.

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