Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections

Abstract Vascular graft or endograft Infections (VGEI) are rare but severe complications of vascular reconstructive surgery, and associated with significant mortality and morbidity risk. Positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (PET/CT) has been shown to have a hi...

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Autores principales:	Lars Husmann, Nadia Eberhard, Martin W. Huellner, Bruno Ledergerber, Anna Mueller, Hannes Gruenig, Michael Messerli, Carlos-A. Mestres, Zoran Rancic, Alexander Zimmermann, Barbara Hasse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54d2626d12af46cfaab163b1bc796f84
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spelling	oai:doaj.org-article:54d2626d12af46cfaab163b1bc796f842021-12-02T14:34:03ZImpact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections10.1038/s41598-021-93331-42045-2322https://doaj.org/article/54d2626d12af46cfaab163b1bc796f842021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93331-4https://doaj.org/toc/2045-2322Abstract Vascular graft or endograft Infections (VGEI) are rare but severe complications of vascular reconstructive surgery, and associated with significant mortality and morbidity risk. Positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (PET/CT) has been shown to have a high diagnostic accuracy in the detection of VGEI. In this single-center prospective cohort study, we assessed the rate and the impact on patient management of relevant unknown incidental findings in PET/CT of patients with proven or suspected VGEI, and clinical follow-up of all patients was performed. Our study results show a comparably high rate of relevant unknown incidental findings (181 in 502 examinations), with documented direct impact on patient management in 80 of 181 (44%) of all findings. PET/CT scan- and patient-based evaluation revealed impact on patient management in 76 of 502 (17%) of all PET/CT scans, and in 59 of 162 (36%) of all patients, respectively. Furthermore, PET/CT correctly identified the final diagnosis in 20 of 36 (56%) patients without VGEI. In conclusion, in proven and suspected VGEI, PET/CT detects a high rate of relevant unknown incidental findings with high impact on patient management.Lars HusmannNadia EberhardMartin W. HuellnerBruno LedergerberAnna MuellerHannes GruenigMichael MesserliCarlos-A. MestresZoran RancicAlexander ZimmermannBarbara HasseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lars Husmann Nadia Eberhard Martin W. Huellner Bruno Ledergerber Anna Mueller Hannes Gruenig Michael Messerli Carlos-A. Mestres Zoran Rancic Alexander Zimmermann Barbara Hasse Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
description	Abstract Vascular graft or endograft Infections (VGEI) are rare but severe complications of vascular reconstructive surgery, and associated with significant mortality and morbidity risk. Positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (PET/CT) has been shown to have a high diagnostic accuracy in the detection of VGEI. In this single-center prospective cohort study, we assessed the rate and the impact on patient management of relevant unknown incidental findings in PET/CT of patients with proven or suspected VGEI, and clinical follow-up of all patients was performed. Our study results show a comparably high rate of relevant unknown incidental findings (181 in 502 examinations), with documented direct impact on patient management in 80 of 181 (44%) of all findings. PET/CT scan- and patient-based evaluation revealed impact on patient management in 76 of 502 (17%) of all PET/CT scans, and in 59 of 162 (36%) of all patients, respectively. Furthermore, PET/CT correctly identified the final diagnosis in 20 of 36 (56%) patients without VGEI. In conclusion, in proven and suspected VGEI, PET/CT detects a high rate of relevant unknown incidental findings with high impact on patient management.
format	article
author	Lars Husmann Nadia Eberhard Martin W. Huellner Bruno Ledergerber Anna Mueller Hannes Gruenig Michael Messerli Carlos-A. Mestres Zoran Rancic Alexander Zimmermann Barbara Hasse
author_facet	Lars Husmann Nadia Eberhard Martin W. Huellner Bruno Ledergerber Anna Mueller Hannes Gruenig Michael Messerli Carlos-A. Mestres Zoran Rancic Alexander Zimmermann Barbara Hasse
author_sort	Lars Husmann
title	Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
title_short	Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
title_full	Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
title_fullStr	Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
title_full_unstemmed	Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections
title_sort	impact of unknown incidental findings in pet/ct examinations of patients with proven or suspected vascular graft or endograft infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54d2626d12af46cfaab163b1bc796f84
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Impact of unknown incidental findings in PET/CT examinations of patients with proven or suspected vascular graft or endograft infections

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