Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study

Tuberculosis (TB) can cause chronic inflammation. The occurrence of aortic aneurysm (AA) and aortic dissection (AD) may be associated with chronic inflammatory disease, but whether TB increases the risk of AA and AD remains to be determined. This study aimed to investigate the association between TB...

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Autores principales:	Ming-Tsung Chen, Chi-Hsiang Chung, Hung-Yen Ke, Chung-Kan Peng, Wu-Chien Chien, Chih-Hao Shen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tuberculosis aortic aneurysm aortic dissection Medicine R
Acceso en línea:	https://doaj.org/article/54d324c51e8646b09885aef4e9e2d3e2
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spelling	oai:doaj.org-article:54d324c51e8646b09885aef4e9e2d3e22021-11-11T16:13:15ZRisk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study10.3390/ijerph1821110751660-46011661-7827https://doaj.org/article/54d324c51e8646b09885aef4e9e2d3e22021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11075https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Tuberculosis (TB) can cause chronic inflammation. The occurrence of aortic aneurysm (AA) and aortic dissection (AD) may be associated with chronic inflammatory disease, but whether TB increases the risk of AA and AD remains to be determined. This study aimed to investigate the association between TB and the development of AA and AD. We conducted a population-based cohort study using data obtained from the Taiwan National Health Insurance Database. We selected 31,220 individuals with TB and 62,440 individuals without TB by matching the cohorts according to age, sex, and index year at a ratio of 1:2. Cox regression analysis revealed that the TB cohort had a 1.711-fold higher risk of AA and AD than the non-TB cohort after adjustment for sex, age, socioeconomic status, and comorbidities (adjusted hazard ratio = 1.711; 95% confidence interval = 1.098–2.666). Patients with pulmonary, extrapulmonary, and miliary TB had a 1.561-, 1.892-, and 8.334-fold higher risk of AA and AD, respectively. Furthermore, patients with TB at <6 months, 6–12 months, and 1–5 years of follow-up had a 6.896-, 2.671-, and 2.371-fold risk of AA and AD, respectively. Physicians should consider the subsequent development of AA and AD while treating patients with TB.Ming-Tsung ChenChi-Hsiang ChungHung-Yen KeChung-Kan PengWu-Chien ChienChih-Hao ShenMDPI AGarticletuberculosisaortic aneurysmaortic dissectionMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11075, p 11075 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tuberculosis aortic aneurysm aortic dissection Medicine R
spellingShingle	tuberculosis aortic aneurysm aortic dissection Medicine R Ming-Tsung Chen Chi-Hsiang Chung Hung-Yen Ke Chung-Kan Peng Wu-Chien Chien Chih-Hao Shen Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
description	Tuberculosis (TB) can cause chronic inflammation. The occurrence of aortic aneurysm (AA) and aortic dissection (AD) may be associated with chronic inflammatory disease, but whether TB increases the risk of AA and AD remains to be determined. This study aimed to investigate the association between TB and the development of AA and AD. We conducted a population-based cohort study using data obtained from the Taiwan National Health Insurance Database. We selected 31,220 individuals with TB and 62,440 individuals without TB by matching the cohorts according to age, sex, and index year at a ratio of 1:2. Cox regression analysis revealed that the TB cohort had a 1.711-fold higher risk of AA and AD than the non-TB cohort after adjustment for sex, age, socioeconomic status, and comorbidities (adjusted hazard ratio = 1.711; 95% confidence interval = 1.098–2.666). Patients with pulmonary, extrapulmonary, and miliary TB had a 1.561-, 1.892-, and 8.334-fold higher risk of AA and AD, respectively. Furthermore, patients with TB at <6 months, 6–12 months, and 1–5 years of follow-up had a 6.896-, 2.671-, and 2.371-fold risk of AA and AD, respectively. Physicians should consider the subsequent development of AA and AD while treating patients with TB.
format	article
author	Ming-Tsung Chen Chi-Hsiang Chung Hung-Yen Ke Chung-Kan Peng Wu-Chien Chien Chih-Hao Shen
author_facet	Ming-Tsung Chen Chi-Hsiang Chung Hung-Yen Ke Chung-Kan Peng Wu-Chien Chien Chih-Hao Shen
author_sort	Ming-Tsung Chen
title	Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
title_short	Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
title_full	Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
title_fullStr	Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
title_full_unstemmed	Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study
title_sort	risk of aortic aneurysm and dissection in patients with tuberculosis: a nationwide population-based cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/54d324c51e8646b09885aef4e9e2d3e2
work_keys_str_mv	AT mingtsungchen riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy AT chihsiangchung riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy AT hungyenke riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy AT chungkanpeng riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy AT wuchienchien riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy AT chihhaoshen riskofaorticaneurysmanddissectioninpatientswithtuberculosisanationwidepopulationbasedcohortstudy
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Risk of Aortic Aneurysm and Dissection in Patients with Tuberculosis: A Nationwide Population-Based Cohort Study

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