Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas
Abstract To evaluate the diagnostic performance of magnetic resonance imaging (MRI) alone in comparison to positron emission tomography/ magnetic resonance imaging (PET/MRI) in patients with meningiomas. 57 patients with a total of 112 meningiomas of the brain were included. PET/MRI, including a ful...
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Nature Portfolio
2021
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oai:doaj.org-article:54d5ae60aeb24348a8db19dcabd8eb2a2021-12-02T16:55:34ZComparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas10.1038/s41598-021-87866-92045-2322https://doaj.org/article/54d5ae60aeb24348a8db19dcabd8eb2a2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87866-9https://doaj.org/toc/2045-2322Abstract To evaluate the diagnostic performance of magnetic resonance imaging (MRI) alone in comparison to positron emission tomography/ magnetic resonance imaging (PET/MRI) in patients with meningiomas. 57 patients with a total of 112 meningiomas of the brain were included. PET/MRI, including a fully diagnostic contrast enhanced MRI and PET, were acquired. PET/MRI was used as reference standard. The size and location of meningiomas was recorded. Likelihood-ratio chi-square tests were used to calculate p-values within logistic regression in order to compare different models. A multi-level logistic regression was applied to comply the hierarchical data structure. Multi-level regression adjusts for clustering in data was performed. The majority (n = 103) of meningiomas could be identified based on standard MRI sequences compared to PET/MRI. MRI alone achieved a sensitivity of 95% (95% CI 0.78, 0.99) and specificity of 88% (95% CI 0.58, 0.98). Based on intensity of contrast medium uptake, 97 meningiomas could be diagnosed with intense uptake (93.75%). Sensitivity was lowest with 74% for meningiomas < 0.5 cm3, high with 95% for meningiomas > 2cm3 and highest with 100% for meningiomas 0.5–1.0 cm3. Petroclival meningiomas showed lowest sensitivity with 88% compared to sphenoidal meningiomas with 94% and orbital meningiomas with 100%. Specificity of meningioma diagnostic with MRI was high with 100% for sphenoidal and hemispherical-dural meningiomas and meningiomas with 0.5–1.0 and 1.0–2.0 cm3. Overall MRI enables reliable detection of meningiomas compared to PET/MRI. PET/MRI imaging offers highest sensitivity and specificity for small or difficult located meningiomas.Heike C. EinhelligEberhard SiebertHans-C. BauknechtAnna TietzeJosefine GraefChristian FurthDaniel SchulzeMilena MiszczukGeorg BohnerImke SchatkaMarcus R. MakowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Heike C. Einhellig Eberhard Siebert Hans-C. Bauknecht Anna Tietze Josefine Graef Christian Furth Daniel Schulze Milena Miszczuk Georg Bohner Imke Schatka Marcus R. Makowski Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| description |
Abstract To evaluate the diagnostic performance of magnetic resonance imaging (MRI) alone in comparison to positron emission tomography/ magnetic resonance imaging (PET/MRI) in patients with meningiomas. 57 patients with a total of 112 meningiomas of the brain were included. PET/MRI, including a fully diagnostic contrast enhanced MRI and PET, were acquired. PET/MRI was used as reference standard. The size and location of meningiomas was recorded. Likelihood-ratio chi-square tests were used to calculate p-values within logistic regression in order to compare different models. A multi-level logistic regression was applied to comply the hierarchical data structure. Multi-level regression adjusts for clustering in data was performed. The majority (n = 103) of meningiomas could be identified based on standard MRI sequences compared to PET/MRI. MRI alone achieved a sensitivity of 95% (95% CI 0.78, 0.99) and specificity of 88% (95% CI 0.58, 0.98). Based on intensity of contrast medium uptake, 97 meningiomas could be diagnosed with intense uptake (93.75%). Sensitivity was lowest with 74% for meningiomas < 0.5 cm3, high with 95% for meningiomas > 2cm3 and highest with 100% for meningiomas 0.5–1.0 cm3. Petroclival meningiomas showed lowest sensitivity with 88% compared to sphenoidal meningiomas with 94% and orbital meningiomas with 100%. Specificity of meningioma diagnostic with MRI was high with 100% for sphenoidal and hemispherical-dural meningiomas and meningiomas with 0.5–1.0 and 1.0–2.0 cm3. Overall MRI enables reliable detection of meningiomas compared to PET/MRI. PET/MRI imaging offers highest sensitivity and specificity for small or difficult located meningiomas. |
| format |
article |
| author |
Heike C. Einhellig Eberhard Siebert Hans-C. Bauknecht Anna Tietze Josefine Graef Christian Furth Daniel Schulze Milena Miszczuk Georg Bohner Imke Schatka Marcus R. Makowski |
| author_facet |
Heike C. Einhellig Eberhard Siebert Hans-C. Bauknecht Anna Tietze Josefine Graef Christian Furth Daniel Schulze Milena Miszczuk Georg Bohner Imke Schatka Marcus R. Makowski |
| author_sort |
Heike C. Einhellig |
| title |
Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| title_short |
Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| title_full |
Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| title_fullStr |
Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| title_full_unstemmed |
Comparison of diagnostic value of 68 Ga-DOTATOC PET/MRI and standalone MRI for the detection of intracranial meningiomas |
| title_sort |
comparison of diagnostic value of 68 ga-dotatoc pet/mri and standalone mri for the detection of intracranial meningiomas |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/54d5ae60aeb24348a8db19dcabd8eb2a |
| work_keys_str_mv |
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