Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantiall...

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Autores principales:	Chenjie Wan, Nadine Bachmann, Venelin Mitov, François Blanquart, Susana Posada Céspedes, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jacques Fellay, Volker Roth, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Laura Walti, Alexandra Calmy, Pietro Vernazza, Enos Bernasconi, Matthias Cavassini, Karin J. Metzner, Huldrych F. Günthard, Roger D. Kouyos, the Swiss HIV Cohort Study
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/54db3420370e48abb6575e57f0049a6a
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spelling	oai:doaj.org-article:54db3420370e48abb6575e57f0049a6a2021-12-02T16:49:46ZHeritability of the HIV-1 reservoir size and decay under long-term suppressive ART10.1038/s41467-020-19198-72041-1723https://doaj.org/article/54db3420370e48abb6575e57f0049a6a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19198-7https://doaj.org/toc/2041-1723The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantially to the HIV-1 reservoir size.Chenjie WanNadine BachmannVenelin MitovFrançois BlanquartSusana Posada CéspedesTeja TurkKathrin NeumannNiko BeerenwinkelJasmina BogojeskaJacques FellayVolker RothJürg BöniMatthieu PerreauThomas KlimkaitSabine YerlyManuel BattegayLaura WaltiAlexandra CalmyPietro VernazzaEnos BernasconiMatthias CavassiniKarin J. MetznerHuldrych F. GünthardRoger D. Kouyosthe Swiss HIV Cohort StudyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenjie Wan Nadine Bachmann Venelin Mitov François Blanquart Susana Posada Céspedes Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jacques Fellay Volker Roth Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Laura Walti Alexandra Calmy Pietro Vernazza Enos Bernasconi Matthias Cavassini Karin J. Metzner Huldrych F. Günthard Roger D. Kouyos the Swiss HIV Cohort Study Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
description	The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantially to the HIV-1 reservoir size.
format	article
author	Chenjie Wan Nadine Bachmann Venelin Mitov François Blanquart Susana Posada Céspedes Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jacques Fellay Volker Roth Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Laura Walti Alexandra Calmy Pietro Vernazza Enos Bernasconi Matthias Cavassini Karin J. Metzner Huldrych F. Günthard Roger D. Kouyos the Swiss HIV Cohort Study
author_facet	Chenjie Wan Nadine Bachmann Venelin Mitov François Blanquart Susana Posada Céspedes Teja Turk Kathrin Neumann Niko Beerenwinkel Jasmina Bogojeska Jacques Fellay Volker Roth Jürg Böni Matthieu Perreau Thomas Klimkait Sabine Yerly Manuel Battegay Laura Walti Alexandra Calmy Pietro Vernazza Enos Bernasconi Matthias Cavassini Karin J. Metzner Huldrych F. Günthard Roger D. Kouyos the Swiss HIV Cohort Study
author_sort	Chenjie Wan
title	Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
title_short	Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
title_full	Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
title_fullStr	Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
title_full_unstemmed	Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
title_sort	heritability of the hiv-1 reservoir size and decay under long-term suppressive art
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/54db3420370e48abb6575e57f0049a6a
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Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

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