Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART

The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantiall...

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Main Authors: Chenjie Wan, Nadine Bachmann, Venelin Mitov, François Blanquart, Susana Posada Céspedes, Teja Turk, Kathrin Neumann, Niko Beerenwinkel, Jasmina Bogojeska, Jacques Fellay, Volker Roth, Jürg Böni, Matthieu Perreau, Thomas Klimkait, Sabine Yerly, Manuel Battegay, Laura Walti, Alexandra Calmy, Pietro Vernazza, Enos Bernasconi, Matthias Cavassini, Karin J. Metzner, Huldrych F. Günthard, Roger D. Kouyos, the Swiss HIV Cohort Study
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/54db3420370e48abb6575e57f0049a6a
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Internet

https://doaj.org/article/54db3420370e48abb6575e57f0049a6a

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